3,4-二甲氧基苯乙胺合成路线 (共 365 条)
反应条件
Yield given. Multistep reaction;
参考文献
Lamas, Carlos; Castedo, Luis; Dominguez, Domingo
Tetrahedron Letters, 1988 , vol. 29, # 31 p. 3865 - 3868
反应条件
1: With trichlorophosphate in toluene
T=140°C; Bischler-Napieralski reaction; 0.5 h; Microwave irradiation;
2: With sodium hydroxide in water
pH=8; Cooling;
参考文献
Awuah, Emelia; Capretta, Alfredo
Journal of Organic Chemistry, 2010 , vol. 75, # 16 p. 5627 - 5634
反应条件
1: 20percent aq. sodium hydroxide / diethyl ether / Ambient temperature
2: phosphorus pentoxide, phosphorus oxychloride / xylene / 3 h / Heating
View Scheme
参考文献
Wendlandt, Alison E.; Stahl, Shannon S.
Journal of the American Chemical Society, 2014 , vol. 136, # 1 p. 506 - 512
反应条件
1.1: methanol / 16 h / 20 °C
1.2: 3 h / |Reflux
2.1: 1,10-Phenanthroline-5,6-dione; zinc(II) iodide; pyridinium p-toluenesulfonate; oxygen / acetonitrile / 24 h / 20 °C
View Scheme
参考文献
Wendlandt, Alison E.; Stahl, Shannon S.
Journal of the American Chemical Society, 2014 , vol. 136, # 1 p. 506 - 512
反应条件
triethylamine in methanol; diethyl ether; isopropyl alcohol
参考文献
Otsuka Pharmaceutical Co., Ltd.
Patent: US4147869 A1, 1979 ;
US 4147869 A
反应条件
in anhydrous xylene
4 h; RefluxDean-Stark;
参考文献
Vilhanova, Beata; Matousek, Vaclav; Vaclavik, Jiri; Syslova, Kamila; Prech, Jan; Pechacek, Jan; Sot, Petr; Januscak, Jakub; Toman, Jaromir; Zapal, Jakub; Kuzma, Marek; Kacer, Petr
Tetrahedron Asymmetry, 2013 , vol. 24, # 1 p. 50 - 55
反应条件
sodium carbonate in chloroform; water
1 h; Ambient temperature; Yield given;
参考文献
Patra, Amarendra; Mukhopadhyay, Prabir K.; Mitra, Alok K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 7 p. 561 - 562
反应条件
ethanol; silver(l) oxide
参考文献
Spaeth; Meinhard
Chemische Berichte, 1942 , vol. 75, p. 400,404
反应条件
sodium methylate in methanol; toluene
T=110°C; P=760.051 Torr;
参考文献
ACTELION PHARMACEUTICALS LTD; ERBECK, Silke; KOBERSTEIN, Ralf; SOI, Antonio; ZISTLER, Andrea
Patent: WO2010/64212 A1, 2010 ;
Location in patent: Page/Page column 25; 26 ;
反应条件
in toluene
90 h; Reflux; Product distribution / selectivity;
参考文献
ACTELION PHARMACEUTICALS LTD; ERBECK, Silke; KOBERSTEIN, Ralf; SOI, Antonio; ZISTLER, Andrea
Patent: WO2010/64212 A1, 2010 ;
Location in patent: Page/Page column 25 ;