3,4-二甲氧基苯乙胺合成路线 （共 365 条）
参考文献
Glusa; Gruner; Hagen; Lohmann; Foken
Pharmazie, 1990 , vol. 45, # 6 p. 408 - 410
反应条件
sodium hydroxide in dichloromethane; water
T=20°C;
参考文献
Christopher, John A.; Atkinson, Francis L.; Bax, Benjamin D.; Brown, Murray J.B.; Champigny, Aurelie C.; Chuang, Tsu Tshen; Jones, Emma J.; Mosley, Julie E.; Musgrave, James R.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 8 p. 2230 - 2234
参考文献
Sun, Lijun; Ono, Mitsunori; Wada, Yumiko; Ying, Weiwen; Przewloka, Teresa; Kostik, Elena
Patent: US2004/198725 A1, 2004 ;
Location in patent: Page 6-7 ;
反应条件
triethylamine in dichloromethane
T=0°C; 2 - 3 h;
参考文献
Kim, Jungho; Lee, Sangphil; Choi, Junyoung; Paik, Young-Ki; Lee, Yousuk; Joo, Hyungmin
Patent: US2009/221829 A1, 2009 ;
Location in patent: Page/Page column 35 ;
US 20090221829 A1
反应条件
triethylamine in ethyl acetate
T=20°C; 1 h;
参考文献
Graulich, Amaury; Scuvee-Moreau, Jacqueline; Alleva, Livia; Lamy, Cedric; Waroux, Olivier; Seutin, Vincent; Liegeois, Jean-Francois
Journal of Medicinal Chemistry, 2006 , vol. 49, # 24 p. 7208 - 7214
反应条件
1: 2-(3,4-dimethoxyphenyl)-ethylamine; 4-formyl-3,5-dimethoxyphenoxy-Merrifield resin With sodium tris(acetoxy)borohydride in acetic acid; N,N-dimethyl-formamide
T=20°C; Solid phase reaction; reductive amination; 69 h;
2: butyric acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide in N,N-dimethyl-formamide
T=20°C; Solid phase reaction; acylation; 15 h;
3: With dimethylsulfide; water; trifluoroacetic acid in dichloromethane
T=20°C; Solid phase reaction; cleavage of amide; 15 h;
参考文献
Pegurier, C.Ecile; Curtet, Sophie; Nicolas, Jean-Paul; Boutin, Jean A.; Delagrange, Philippe; Renard, Pierre; Langlois, Michel
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 1 p. 163 - 171
反应条件
1: in methanol
2: T=175 - 178°C;
参考文献
Saidov; Alimova; Levkovich; Vinogradova
Chemistry of Natural Compounds, 2013 , vol. 49, # 2 p. 302 - 304
Khim. Prir. Soedin., 2013 , vol. 49, # 2 p. 257 - 258,2
参考文献
Stenlake; Waigh; Urwin; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 6 p. 508 - 514
反应条件
sodium cyanoborohydride in methanol
72 h;
参考文献
Stout, David M.; Gorczynski, Richard J.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 326 - 328
反应条件
1: 64 percent / triethylamine / ethyl acetate / 1 h / 20 °C
2: phosphorus pentoxide / toluene / 0.5 h / Heating
3: acetonitrile / 2 h / Heating
View Scheme
参考文献
Graulich, Amaury; Scuvee-Moreau, Jacqueline; Alleva, Livia; Lamy, Cedric; Waroux, Olivier; Seutin, Vincent; Liegeois, Jean-Francois
Journal of Medicinal Chemistry, 2006 , vol. 49, # 24 p. 7208 - 7214
