3,4-二甲氧基苯乙胺合成路线 （共 365 条）
反应条件
1: 83 percent / 20percent K2CO3 / CHCl3 / 3 h / Ambient temperature
2: 82 percent / phosphorus oxychloride / acetonitrile / 2 h / Heating
3: 85 percent / decalin / 10percent Pd/C / 15 h / Heating
4: 53 percent / H2 / Raney Ni / ethanol / 2844.3 Torr
5: triethylamine / CHCl3 / 0.25 h / Ambient temperature
View Scheme
参考文献
Walker; Boots; Stubbins; Rogers; Davis
Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 174 - 181
反应条件
triethylamine in benzene
参考文献
Gupta, R. C.; Pratap, Ram; Prasad, C. R.; Anand, Nitya
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 4 p. 344 - 347
反应条件
in N,N-dimethyl-formamide
RefluxInert atmosphere;
参考文献
Modh, Rahul P.; Patel, Amit C.; Chikhalia, Kishor H.
Medicinal Chemistry, 2012 , vol. 8, # 2 p. 182 - 192
反应条件
in N,N-dimethyl-formamide
Heating;
参考文献
Priimenko, B. A.; Samura, B. A.; Garmash, S. N.; Klyuev, N. A.; Romanenko, N. I.
Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 2 p. 105 - 108
Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 2 p. 160 - 164
反应条件
var. amines; Product distribution;
参考文献
Baraldi; Vicentini; Simoni; Guarneri
Farmaco, Edizione Scientifica, 1983 , vol. 38, # 6 p. 369 - 375
反应条件
1: benzene / Heating
2: 90 percent / m-chloroperoxybenzoic acid / benzene / 3 h
View Scheme
参考文献
Kuehne, Martin E.; Parsons, W. H.
Tetrahedron, 1983 , vol. 39, # 22 p. 3763 - 3766
反应条件
dicyclohexyl-carbodiimide in dichloromethane
standing overnight;
参考文献
Archer; Okaniwa; Schepis; et al.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, # 2 p. 357 - 361
参考文献
Kikkawa
Yakugaku Zasshi, 1959 , vol. 79, p. 83,86
Chem.Abstr., 1959 , p. 10269
反应条件
1: 100 percent / 50 - 60 °C
2: 88 percent / sodium borohydride
View Scheme
参考文献
Takano, Seiichi; Sato, Masayuki; Ogasawara, Kunio
Heterocycles, 1981 , vol. 16, # 5 p. 799 - 801
反应条件
1.1: sodium periodate
2.1: sodium hydride / 0.02 h
2.2: 25 °C
3.1: lithium aluminum hydride / tetrahydrofuran / 3 h / Heating
4.1: toluene / 1 h / Heating
View Scheme
参考文献
Takano, Seiichi; Sato, Masayuki; Ogasawara, Kunio
Heterocycles, 1981 , vol. 16, # 5 p. 799 - 801
