3,4-二甲氧基苯乙胺合成路线 （共 365 条）
反应条件
1.) Schotten-Baumann reaction, 2.) hydrolysis; Multistep reaction;
参考文献
Vinogradova, V. I.; Yunusov, M. S.
Chemistry of Natural Compounds, 1984 , vol. 20, # 3 p. 308 - 311
Khimiya Prirodnykh Soedinenii, 1984 , # 3 p. 331 - 334
反应条件
1: 2.) NaBH4 / 1.) 120 deg C, 2.) CHCl3, EtOH, r.t.
2: 1.) H3BO3, 2.) NaBH4 / 1.) CH3OH, H2O, r.t.
View Scheme
参考文献
Vinogradova, V. I.; Golodnyuk, T. I.; Yunusov, M. S.; Suleimanova, G. A.; Tulyaganov, N.
Chemistry of Natural Compounds, 1993 , vol. 29, # 5 p. 654 - 657
Khimiya Prirodnykh Soedinenii, 1993 , # 5 p. 736 - 740
反应条件
1: 72 percent / AcOH / 0.33 h / Heating
2: 48 percent / phenyliodine(III) bis(trifluoroacetate); BF3*OEt2 / CH2Cl2 / 0.67 h / -20 °C
View Scheme
参考文献
Moreno, Isabel; Tellitu, Imanol; Dominguez, Esther; SanMartin, Raul
European Journal of Organic Chemistry, 2002 , # 13 p. 2126 - 2135
参考文献
ALTANA PHARMA AG
Patent: WO2005/3129 A1, 2005 ;
Location in patent: Page 88 ;
WO 2005/003129 A1
反应条件
diisopropyl-carbodiimide in N,N-dimethyl-formamide
T=20°C;
参考文献
Adhikari, Raju; Jones, Dionne A.; Liepa, Andris J.; Nearn, Roland H.
Australian Journal of Chemistry, 2005 , vol. 58, # 12 p. 882 - 890
参考文献
Gazit, Aviv; Osherov, Nir; Posner, Israel; Yaish, Pnina; Poradosu, Enrique; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 6 p. 1896 - 1907
参考文献
Chan, Winghong; Lee, Albert W. M.; Jiang, Lasheng
Tetrahedron Letters, 1995 , vol. 36, # 5 p. 715 - 718
反应条件
1: molecular sieves 4 Angstroem / CH2Cl2 / 18 h / 20 °C
2: 34 percent / gold(III) chloride; silver(I) trifluoromethanesulfonate / 1,2-dichloro-ethane / 24 h / 80 °C
View Scheme
参考文献
Gruessner et al.
Helvetica Chimica Acta, 1959 , vol. 42, p. 2431,2436
反应条件
2: P2O5; toluene
View Scheme
参考文献
Child; Pyman
Journal of the Chemical Society, 1931 , p. 36,47
反应条件
1,1'-carbonyldiimidazole in tetrahydrofuran
参考文献
LeGendre, Onica; Pecic, Stevan; Chaudhary, Sandeep; Zimmerman, Sarah M.; Fantegrossi, William E.; Harding, Wayne W.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 2 p. 628 - 631
