3,4-二甲氧基苯乙胺合成路线 （共 365 条）
反应条件
in benzene
RefluxDean-Stark;
参考文献
Zhurakulov; Vinogradova; Levkovich
Chemistry of Natural Compounds, 2013 , vol. 49, # 1 p. 70 - 74
Khim. Prir. Soedin., 2013 , # 1 p. 62 - 66,5
反应条件
1: 92 percent / 2 h / 190 - 210 °C
2: phosphoryl chloride / toluene / 3 h / Heating
View Scheme
参考文献
Steiner, Michel A.; Gatfield, John; Brisbare-Roch, Catherine; Dietrich, Hendrik; Treiber, Alexander; Jenck, Francois; Boss, Christoph
ChemMedChem, 2013 , vol. 8, # 6 p. 898 - 903
反应条件
T=200°C; 1 h; microwave irradiation;
参考文献
Baxendale, Ian R.; Davidson, Thomas D.; Ley, Steven V.; Perni, Remedios H.
Heterocycles, 2003 , vol. 60, # 12 p. 2707 - 2715
反应条件
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C
2: potassium carbonate / ethanol / 12 h / |Reflux
View Scheme
参考文献
Xu, Zi-Chen; Wang, Xiao-Bing; Yu, Wen-Ying; Xie, Sai-Sai; Li, Su-Yi; Kong, Ling-Yi
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 10 p. 2368 - 2373
反应条件
1: 2 h / |Cooling with ice; |Reflux; |Inert atmosphere
2: phosphorus pentachloride / dichloromethane / 1.5 h / 35 - 40 °C / |Inert atmosphere
3: diethyl ether / 20 °C / |Inert atmosphere
4: water / 20 °C
5: tetrahydrofuran / 72 h / 40 °C / |Inert atmosphere
6: potassium hexamethylsilazane / tetrahydrofuran / 0 °C / |Inert atmosphere
7: sodium cyanoborohydride / ethanol; tetrahydrofuran / 13 h / 0 - 20 °C / |Inert atmosphere
8: palladium 10 on activated carbon; hydrogen / methanol / 2 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Orejarena Pacheco, Julio Cesar; Lahm, Guenther; Opatz, Till
Journal of Organic Chemistry, 2013 , vol. 78, # 10 p. 4985 - 4992
反应条件
hydrogen; palladium on activated charcoal
参考文献
Kindler,K.; Luehrs,K.
Justus Liebigs Annalen der Chemie, 1967 , vol. 707, p. 26 - 34
反应条件
1: pyridine / benzene / 20 °C
2: POCl3 / acetonitrile / Heating
View Scheme
参考文献
Cortes Cortes; Cortes Romero; Gutierrez Ramirez
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 6 p. 1425 - 1427
反应条件
hydrogen; nickel monoaluminide; palladium in diethyl ether; ethyl acetate
参考文献
Eli Lilly and Company
Patent: US3987200 A1, 1976 ;
反应条件
T=170°C; Condensation; 2 h;
参考文献
Erb, Benedicte; Akue, Rufine; Rigo, Benoit; Pirotte, Bernard; Couturier, Daniel
Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 2 p. 253 - 260
反应条件
in benzene
4 h; Ambient temperature;
参考文献
Stezhko, T. V.; Granik, V. G.; Kadushkin, A. V.; Glushkov, R. G.; Roshchina, L. F.; et al.
Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 10 p. 692 - 697
Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 10 p. 1198 - 1203
