3,4-二甲氧基苯乙胺合成路线 （共 365 条）
反应条件
in dimethyl sulfoxide
参考文献
Tanabe Seiyaku Co., Ltd.
Patent: US4131686 A1, 1978 ;
参考文献
Tanabe Seiyaku Co., Ltd.
Patent: US4131686 A1, 1978 ;
参考文献
Jirkovsky, I.; Noureldin, R.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 449 - 453
反应条件
1: 92 percent / 2 h / 190 - 210 °C
2: phosphoryl chloride / toluene / 3 h / Heating
3: 71 percent / sodium borohydride / 19 h / Ambient temperature
4: 51 percent / benzene / 48 h / Heating
5: 86 percent / acetonitrile / 48 h / Ambient temperature
View Scheme
参考文献
Stenlake; Waigh; Dewar; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 6 p. 515 - 524
反应条件
1: 99 percent / CH2Cl2 / 1 h / 0 °C
2: 82 percent / NaH / tetrahydrofuran / 4 h / Ambient temperature
3: tetrahydrofuran / 48 h / 80 °C
View Scheme
参考文献
Theodore; Nelson
Journal of Organic Chemistry, 1987 , vol. 52, # 7 p. 1309 - 1315
参考文献
Ma, Su; Lin, Lorrie; Raghavan, R.; Cohenour, Pat; Lin, Peter Y. T.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 20 p. 4087 - 4097
反应条件
1: sodium hydroxide / dichloromethane; water / 16 h / 20 °C
2: trichlorophosphate / acetonitrile / 1 h / |Inert atmosphere; |Reflux
3: sodium tetrahydroborate / methanol / 2 h / 20 °C / |Inert atmosphere
4: dichloromethane / 2 h / 20 °C
5: palladium diacetate; potassium carbonate; 2-Ph2P-2'-(Me2N)biphenyl / N,N-dimethyl acetamide / 4 h / 130 °C
6: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / |Reflux
7: potassium hydroxide / methanol / 6 h / 45 °C
View Scheme
参考文献
Moreno, Laura; Cabedo, Nuria; Ivorra, Maria Dolores; Sanz, Maria-Jesus; Castel, Arturo Lopez; Carmen Alvarez; Cortes, Diego
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 17 p. 4824 - 4827
反应条件
1: benzene / und Erwaermen des Reaktionsprodukts mit wss.Aethanol
2: 210 °C / Erwaermen des Reaktionsprodukts in Benzol mit Thionylchlorid und Erhitzen des erhaltenen kristallinen Reaktionsprodukts auf 140grad unter vermindertem Druck
View Scheme
参考文献
Kindler; Peschke
Archiv der Pharmazie (Weinheim, Germany), 1932 , vol. 270, p. 353,359
反应条件
1: diethyl ether / 1.75 h / 0 - 25 °C
2: trichlorophosphate / ethanol; toluene / 3 h / Reflux
3: 10 palladium on activated charcoal; hydrogen / ethanol / 12 h / 750.08 Torr
4: water; lithium hydroxide hydrate / tetrahydrofuran / 0.75 h
View Scheme
参考文献
Koelzer, Michael; Weitzel, Kerstin; Goeringer, H. Ulrich; Thines, Eckhard; Opatz, Till
ChemMedChem, 2010 , vol. 5, # 9 p. 1456 - 1464
参考文献
YUN-CHOI, HYE-SOOK; CHANG, KI CHURL; LEE, DUCK HYUNG
Patent: WO2003/95426 A1, 2003 ;
Location in patent: Page/Page column 41-42 ;
