3,4-二甲氧基苯乙胺合成路线 （共 365 条）
反应条件
1: 99 percent / tetrahydrofuran / 2 h / 25 °C 2: 93 percent / I2; HIO3 / methanol; H2O / 48 h / 85 °C 3: 84 percent / CuI; PPh3; iPr2NH / Pd(PPh3)2Cl2 / 16 h / 25 °C 4: 90 percent / KOH / methanol; H2O / 20 h / 25 °C 5: 98 percent / Cp2TiMe2 / toluene / 16 h / 110 °C 6: HCOOH; NEt3 / Noyori's catalyst / dimethylformamide / 7 h / 25 °C View Scheme
参考文献
Gawley, Robert E.; Smith, Gregory A.
Tetrahedron Letters, 1988 , vol. 29, # 3 p. 301 - 302
反应条件
1: 99 percent / tetrahydrofuran / 2 h / 25 °C 2: 93 percent / I2; HIO3 / methanol; H2O / 48 h / 85 °C 3: 84 percent / CuI; PPh3; iPr2NH / Pd(PPh3)2Cl2 / 16 h / 25 °C 4: 90 percent / KOH / methanol; H2O / 20 h / 25 °C 5: 98 percent / Cp2TiMe2 / toluene / 16 h / 110 °C 6: HCOOH; NEt3 / Noyori's catalyst / dimethylformamide / 7 h / 25 °C View Scheme
参考文献
Gawley, Robert E.; Smith, Gregory A.
Tetrahedron Letters, 1988 , vol. 29, # 3 p. 301 - 302
反应条件
1: 1.) PhCHO, 3.) 2N aq. NaOH 2: K2CO3 / dimethylformamide / 16 h / Ambient temperature View Scheme
参考文献
Dodic, Nerina; Dumaitre, Bernard; Daugan, Alain; Pianetti, Pascal
Journal of Medicinal Chemistry, 1995 , vol. 38, # 13 p. 2418 - 2426
参考文献
Tomita; Takano
Yakugaku Zasshi, 1959 , vol. 79, p. 1331,1333
Chem.Abstr., 1960 , p. 3299
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Beke; Szantay
Acta Chimica Academiae Scientiarum Hungaricae, 1958 , vol. 14, p. 325,328
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Hamlin; Fischer
Journal of the American Chemical Society, 1953 , vol. 75, p. 5119
参考文献
Tomita; Takano
Yakugaku Zasshi, 1959 , vol. 79, p. 1331,1333
Chem.Abstr., 1960 , p. 3299
Full Text Show Details
Beke; Szantay
Acta Chimica Academiae Scientiarum Hungaricae, 1958 , vol. 14, p. 325,328
Full Text Show Details
Hamlin; Fischer
Journal of the American Chemical Society, 1953 , vol. 75, p. 5119
反应条件
1: chloral 2: LiAlH4; THF View Scheme
参考文献
Theodore; Nelson
Journal of Organic Chemistry, 1987 , vol. 52, # 7 p. 1309 - 1315
反应条件
sodium hydroxide; benzaldehyde Yield given. Multistep reaction;
参考文献
Dodic, Nerina; Dumaitre, Bernard; Daugan, Alain; Pianetti, Pascal
Journal of Medicinal Chemistry, 1995 , vol. 38, # 13 p. 2418 - 2426
反应条件
und Erwaermen des Reaktionsprodukts mit wss.Aethanol;
参考文献
Buck
Journal of the American Chemical Society, 1930 , vol. 52, p. 4119,4121
反应条件
benzene und Erwaermen des Reaktionsprodukts mit wss.Aethanol;
参考文献
Kindler; Peschke
Archiv der Pharmazie (Weinheim, Germany), 1932 , vol. 270, p. 353,359
参考文献
Cho, Su-Dong; Song, Sang-Yong; Park, Yong-Dae; Kim, Jeum-Jong; Joo, Woo-Hong; Shiro, Motoo; Falck; Shin, Dong-Soo; Yoon, Yong-Jin
Tetrahedron Letters, 2003 , vol. 44, # 50 p. 8995 - 8998
