3,4-二甲氧基苯乙胺合成路线 （共 365 条）
反应条件
acetic anhydride 1.) 60 deg C, 30 min, 2.) 20 deg C, overnight;
参考文献
Tetrahedron, , vol. 54, # 26 p. 7485 - 7496
反应条件
n-butyllithium in tetrahydrofuran T=0°C; 16 h;
参考文献
Tetrahedron Letters, , vol. 29, # 31 p. 3865 - 3868
反应条件
in methanol 12 h; Ambient temperature;
参考文献
Tetrahedron, , vol. 39, # 6 p. 905 - 912
参考文献
Journal of Scientific and Industrial Research, , vol. 17B, p. 219,223
反应条件
in N,N-dimethyl-formamide
参考文献
Pola Chemical Industries, Inc.
Patent: US5391552 A1, 1995 ;
反应条件
1: 60 percent / triethylamine / diethyl ether / 1 h / Ambient temperature 2: 72 percent / dimethylformamide / 56 h / 100 °C / The effect of various reaction time, solvents, reaction temperature, and reagents rate was studied. View Scheme
参考文献
Hocquaux; Marcot; Redeuilh; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 319 - 329
反应条件
1: 81 percent / 6 h / 140 °C 2: 60 percent / POCl3 / toluene; ethanol / 3.5 h / Heating 3: hydrogen / platinum on activated charcoal / ethanol / 6 h / 20 °C / 760 Torr 4: 66 percent / LiAlH4 / tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Silveira, Claudio C.; Bernardi, Carmem R.; Braga, Antonio L.; Kaufman, Teodoro S.
Tetrahedron Letters, 1999 , vol. 40, # 27 p. 4969 - 4972
反应条件
acetic acid in acetonitrile 18 h; Heating;
参考文献
Singh
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1989 , vol. 28, # 10 p. 802 - 805
反应条件
in ethylene glycol dimethyl ether
参考文献
SmithKline Beecham Corporation
Patent: US5393788 A1, 1995 ;
US 5393788 A
反应条件
hydrogenchloride T=150°C;
参考文献
Barger; Ewins
Journal of the Chemical Society, 1910 , vol. 97, p. 2260
