3,4-二甲氧基苯乙胺合成路线 (共 365 条)
参考文献
Mannich; Jacobsohn
Chemische Berichte, 1910 , vol. 43, p. 193
反应条件
formic acid Pictet-Spengler cyclization; 12 h; Heating;
参考文献
Louafi, Fadila; Hurvois, Jean-Pierre; Chibani, Aissa; Roisnel, Thierry
Journal of Organic Chemistry, 2010 , vol. 75, # 16 p. 5721 - 5724
参考文献
Gawley, Robert E.; Smith, Gregory A.
Tetrahedron Letters, 1988 , vol. 29, # 3 p. 301 - 302
反应条件
1: With trifluoroacetic acid in toluene T=140°C; Pictet-Spengler cyclisation; 0.5 h; Microwave irradiation; 2: With sodium hydroxide in water pH=8; Cooling;
参考文献
Awuah, Emelia; Capretta, Alfredo
Journal of Organic Chemistry, 2010 , vol. 75, # 16 p. 5627 - 5634
反应条件
1: toluene / 2 h / Heating 2: CF3CO2H / toluene / 2 h / Heating View Scheme
参考文献
Gitto, Rosaria; Barreca, Maria Letizia; De Luca, Laura; De Sarro, Giovambattista; Ferreri, Guido; Quartarone, Silvana; Russo, Emilio; Constanti, Andrew; Chimirri, Alba
Journal of Medicinal Chemistry, 2003 , vol. 46, # 1 p. 197 - 200
反应条件
trifluoroacetic acid T=80°C; Pictet-Spengler reaction; 5 h; Inert atmosphereneat (no solvent);
参考文献
Chowdappa, Nagaraja; Sherigara, Bailur Sheena; Augustine, John Kallikat; Areppa, Kummara; Mandal, Ashis Baran
Synthesis, 2010 , # 17 art. no. Z09910SS, p. 2949 - 2956
反应条件
trifluoroacetic acid Heating;
参考文献
Singh, Harjit; Sarin, Rakesh
Journal of Chemical Research, Miniprint, 1988 , # 10 p. 2623 - 2640
反应条件
in bromobenzene T=20°C; Reflux;
参考文献
Marugan, Juan J.; Zheng, Wei; Motabar, Omid; Southall, Noel; Goldin, Ehud; Sidransky, Ellen; Aungst, Ronald A.; Liu, Ke; Sadhukhan, Subir Kumar; Austin, Christopher P.
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 5 p. 1880 - 1897
反应条件
1: 3,4,5-trimethoxy-benzaldehyde; 2-(3,4-dimethoxyphenyl)-ethylamine With formic acid T=110°C; Pictet-Spengler reaction; 2: formaldehyd With formic acid Heating;
参考文献
Ruchirawat, Somsak; Bhavakul, Vanida; Chaisupakitsin, Malinee
Synthetic Communications, 2003 , vol. 33, # 4 p. 621 - 625
参考文献
Stenlake; Waigh; Dewar; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 6 p. 515 - 524