4-乙氧基-3-甲氧基苯甲醛合成路线 （共 41 条）
反应条件
ammonium acetate in butan-1-ol Rodionov reaction; Heating;
参考文献
Russian Journal of General Chemistry, , vol. 75, # 7 p. 1113 - 1124
参考文献
Slotta; Heller
Chemische Berichte, 1930 , vol. 63, p. 3029,3043
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Grassie; Purves
Canadian Journal of Research, Section B: Chemical Sciences, 1948 , vol. 26, p. 677,679
反应条件
ethyl acetate; platinum Hydrogenation;
参考文献
Shepard; Noth
Journal of the American Chemical Society, 1950 , vol. 72, p. 4364,4366
参考文献
Vavon
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1912 , vol. 154, p. 361
Annales de Chimie (Cachan, France), 1914 , vol. <9> 1, p. 166
反应条件
1: sodium hydride / dimethyl sulfoxide / 20 °C
2: sodium tetrahydroborate; boron trifluoride diethyl etherate; dihydrogen peroxide; sodium hydroxide / 20 °C
View Scheme
参考文献
Su, Na; Wang, Zhen-Jun; Wang, Li-Zhong; Zhang, Xiao; Dong, Wei-Li; Wang, Hong-Xue; Li, Zheng-Ming; Zhao, Wei-Guang
Chemical Biology and Drug Design, 2011 , vol. 78, # 1 p. 101 - 111
反应条件
1: palladium/charcoal; ethanol / Hydrogenation
2: acetic acid; concentrated aqueous HNO3
3: KOH / anschliessendes Erwaermen mit Diaethylsulfat
View Scheme
参考文献
Galmarini
Anales de la Asociacion Quimica Argentina (1921-2001), 1951 , vol. 39, p. 92,96
反应条件
1: Na-methylate / dimethylsulfoxide / 0.5 h / 65 - 75 °C
2: HCl cc. / propan-2-ol / 1 h / Heating
3: 67 percent / Na-methylate / ethanol / 24 h / Heating
View Scheme
参考文献
EGIS Gyogyszergyar
Patent: US4883798 A1, 1989 ;
反应条件
ethanol; ammonia; nickel
T=40 - 90°C; P=73550.8 Torr; Hydrogenation.aus dem in geringer Menge erhaltenen Reaktionsprodukts (Kp0.5: 260-270grad) und Phenylisocyanat;
参考文献
Gardner; Mitchell; Purves
Canadian Journal of Research, Section B: Chemical Sciences, 1948 , vol. 26, p. 668,674, 676
反应条件
1: With orthoformic acid triethyl ester; boron trifluoride diethyl etherate in diethyl ether
T=100°C; 24 h; Heating / reflux;
2: With sodium hydroxide; water in diethyl ether
T=20°C;
参考文献
Shanghai Ecust Biomedicine Co., Ltd; Zhejiang Wild Wind Pharmaceutical Co., Ltd
Patent: EP2351730 A1, 2011 ;
Location in patent: Page/Page column 9 ;
反应条件
bromine; acetic acid
参考文献
Stermitz; Gillespie; Amoros; Romero; Larson; Earl; Ogg
Journal of Medicinal Chemistry, 1975 , vol. 18, # 7 p. 708 - 713
