3-氨基-4-甲氧基苯甲酰苯胺合成路线 (共 3 条)
反应条件
1: 3-amino-4-methoxy-benzoic acid With benzotriazol-1-ol; diisopropyl-carbodiimide in dichloromethane T=20°C; 0.5 h; 2: aniline in dichloromethane 3 h;
参考文献
Hao, Lan-Hu; Li, Yan-Ping; He, Wei-Ying; Wang, Hui-Qiang; Shan, Guang-Zhi; Jiang, Jian-Dong; Li, Yu-Huan; Li, Zhuo-Rong
European Journal of Medicinal Chemistry, 2012 , vol. 55, p. 117 - 124
参考文献
Toms River Chemical Corporation
Patent: US4283556 A1, 1981 ;
反应条件
1: 3-hydroxy-[2]naphthoic acid-(5-chloro-2-methoxy-anilide) in water T=20 - 80°C; Alkaline conditions; 2: C14H12N3O2(1+)*Na(1+) With sodium acetate; acetic acid in water T=20 - 35°C; pH=4.8 - 5.0; Micro-reactor; Product distribution / selectivity;
参考文献
WO2005/105928 A1, ;
Page/Page column 15-18 ;