2 - (2,4-二氯苯氧基)乙醇合成路线 （共 21 条）
反应条件
sodium hydroxide; oxygen; Bi(NO3)3; palladium on activated charcoal T=90°C; 1.5 h; Title compound not separated from byproducts;
参考文献
Fiege, Helmut; Wedemeyer, Karlfried
Angewandte Chemie, 1981 , vol. 93, # 9 p. 812 - 813
反应条件
phosphorus tribromide in ethylene glycol dimethyl ether T=0 - 20°C; 20 h;
参考文献
Eisai Co., Ltd.
Patent: EP1375484 A1, 2004 ;
Location in patent: Page 14 ;
反应条件
1: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane
T=20°C; 0.5 h;
2: With sodium tetrahydroborate; water in tetrahydrofuran
T=0°C; 0.5 h;
参考文献
Morales-Serna, Jose Antonio; Garcia-Rios, Erendira; Bernal, Jorge; Paleo, Ehecatl; Gavino, Ruben; Cardenas, Jorge
Synthesis, 2011 , # 9 art. no. M12811SS, p. 1375 - 1382
反应条件
potassium carbonate in dimethyl sulfoxide
T=60°C; 6 h;
参考文献
Yamansarova; Kukovinets; Zainullin; Galin; Kunakova; Zorin; Tolstikov
Russian Journal of Organic Chemistry, 2001 , vol. 37, # 2 p. 246 - 255
反应条件
lithium aluminium tetrahydride in diethyl ether
T=0 - 20°C; 2 h;
参考文献
Yamansarova; Kukovinets; Zainullin; Galin; Kunakova; Zorin; Tolstikov
Russian Journal of Organic Chemistry, 2001 , vol. 37, # 2 p. 246 - 255
参考文献
Newman; Fones; Renoll
Journal of the American Chemical Society, 1947 , vol. 69, p. 718,721
反应条件
pyridinium p-toluenesulfonate in methanol
T=20°C; Hydrolysis;
参考文献
Szajnman, Sergio H.; Yan, Wen; Bailey, Brian N.; Docampo, Roberto; Elhalem, Eleonora; Rodriguez, Juan B.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 9 p. 1826 - 1840
反应条件
1: [3H]-2,4-Dichlorophenoxyacetic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane
T=20°C; 0.5 h;
2: methanol With sodium tetrahydroborate in tetrahydrofuran
T=0°C; 0.5 h;
参考文献
Morales-Serna, Jose Antonio; Garcia-Rios, Erendira; Bernal, Jorge; Paleo, Ehecatl; Gavino, Ruben; Cardenas, Jorge
Synthesis, 2011 , # 9 art. no. M12811SS, p. 1375 - 1382
反应条件
1: [3H]-2,4-Dichlorophenoxyacetic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane
T=20°C; 0.5 h;
2: isopropyl alcohol With sodium tetrahydroborate in tetrahydrofuran
T=0°C; 0.5 h;
参考文献
Morales-Serna, Jose Antonio; Garcia-Rios, Erendira; Bernal, Jorge; Paleo, Ehecatl; Gavino, Ruben; Cardenas, Jorge
Synthesis, 2011 , # 9 art. no. M12811SS, p. 1375 - 1382
反应条件
sulfuric acid
T=170°C;
参考文献
Dow Chem. Co.
Patent: DE929484 , 1952 ;
