反应条件
1.1: toluene-4-sulfonic acid / ethanol / 1.5 h / Reflux
2.1: trichlorophosphate / 1,2-dichloro-benzene / 1.5 h / 20 °C
2.2: 4 h / 105 °C
2.3: 20 °C
3.1: 3 h / 115 °C / Inert atmosphere
3.2: 1 h / 20 °C / Molecular sieve; Inert atmosphere
4.1: sodium carbonate; p-toluenesulfonyl chloride / tetrahydrofuran; water / 2 h / 20 °C
4.2: 12 h
4.3: 0 °C / pH 10
5.1: acetone / 48 h / Darkness
View Scheme
参考文献
Vehar, Blaz; Hrast, Martina; Kovac, Andreja; Konc, Janez; Mariner, Katherine; Chopra, Ian; O'Neill, Alex; Janezic, Dusanka; Gobec, Stanislav
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 17 p. 5137 - 5146
