反应条件
1.1: methylmagnesium bromide / tetrahydrofuran; 2-methyl tetrahydrofuran / 0.67 h / 0 - 2 °C
1.2: 2.5 h / 20 - 60 °C / |Cooling with ice
2.1: sodium t-butanolate / N,N-dimethyl-formamide / 1.25 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BUTTERWORTH, Sam; FINLAY, Maurice, Raymond, Verschoyle; WARD, Richard, Andrew; KADAMBAR, Vasantha, Krishna; CHANDRASHEKAR, Reddy, C.; MURUGAN, Andiappan; REDFEARN, Heather, Marie
Patent: WO2013/14448 A1, 2013 ;
WO 2013/014448 A1