反应条件
1: indole With methylmagnesium bromide in tetrahydrofuran; 2-methyl tetrahydrofuran
T=0 - 2°C; 0.666667 h;
2: 2,4,5-trichloro-pyrimidine in tetrahydrofuran; 2-methyl tetrahydrofuran
T=20 - 60°C; 2.5 h; Cooling with ice;
参考文献
Ward, Richard A.; Anderton, Mark J.; Ashton, Susan; Bethel, Paul A.; Box, Matthew; Butterworth, Sam; Colclough, Nicola; Chorley, Christopher G.; Chuaqui, Claudio; Cross, Darren A.E.; Dakin, Les A.; Debreczeni, Judit E.; Eberlein, Cath; Finlay, M. Raymond V.; Hill, George B.; Grist, Matthew; Klinowska, Teresa C.M.; Lane, Clare; Martin, Scott; Orme, Jonathon P.; Smith, Peter; Wang, Fengjiang; Waring, Michael J.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 17 p. 7025 - 7048
