反应条件
1: 1.) n-butyllithium / 1.) THF, hexane, from -78 deg C to 0 deg C, 1 h, 2.) from -78 deg C to room temp., overnight 2: lithium diisopropylamide / tetrahydrofuran; hexane / 1.) -70 deg C, 1.5 h, 2.) from -70 deg C to -5 deg C, 1 h 3: 50 percent / tetrahydrofuran / -65 - 20 °C View Scheme
参考文献
Mahboobi, Siavosh; Uecker, Andrea; Sellmer, Andreas; Cenac, Christophe; Hoecher, Heymo; Pongratz, Herwig; Eichhorn, Emerich; Hufsky, Harald; Truempler, Antje; Sicker, Marit; Heidel, Florian; Fischer, Thomas; Stocking, Carol; Elz, Sigurd; Boehmer, Frank-D.; Dove, Stefan
Journal of Medicinal Chemistry, 2006 , vol. 49, # 11 p. 3101 - 3115
