Davis, Peter D.; Hill, Christopher H.; Lawton, Geoffrey; Nixon, John S.; Wilkinson, Sandra E.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 1 p. 177 - 184
ethylmagnesium bromide in diethyl ether; benzene examination of further solvents, temperature, reaction time and the quantity of indole; Product distribution;
1: 1.) NaH / 1.) DMF, 0.5 h, 2.) DMF, RT, 18 h 2: CH2Cl2 / 3 h / Ambient temperature 3: Et3N / CH2Cl2 / 18 h / Ambient temperature 4: 94 percent / 33percent aq. ammonia / dimethylformamide / 4 h / 140 °C 5: 73 percent / pyridine / CH2Cl2 / 20 h / Ambient temperature 6: 79 percent / ethanol / 18 h / Heating View Scheme
参考文献
Davis, Peter D.; Elliot, Lucy H.; Harris, William; Hill, Christopher H.; Hurst, Steven A.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 994 - 1001
