反应条件
1: 68 percent / potassium hydride, HMPA / tetrahydrofuran / 20 h / Ambient temperature
2: 1.) tert-butyllithium / 1.) THF, r.t., 2 h; 2.) r.t., overnight
3: 72 percent / sodium hydroxide / methanol / 4 h / Heating
4: 89 percent / ethyl acetate / 5 h / 50 °C
6: 54 percent / triphenylphosphine / dimethylformamide / 86 h / Heating
7: 54 percent / tetrahydrofuran / 1.) r.t., 30 min; 2.) reflux, 1 h
8: 2.) NaBH4 / 1.) MeOH, 50 deg C, 5h; 2.) MeOH, 0 deg C, 1h
View Scheme
参考文献
Kutney; Noda; Lewis; et al.
Canadian Journal of Chemistry, 1982 , vol. 60, # 19 p. 2426 - 2430
