反应条件
1: 1.) ethylmagnesium bromide / 1.) THF, toluene, 45 deg C, 45 min, 2.) THF, toluene, reflux, 2 h
2: 80 percent / 10 percent aq. potassium hydroxide / 0.5 h / Heating
View Scheme
参考文献
Davis, Peter D.; Hill, Christopher H.; Lawton, Geoffrey; Nixon, John S.; Wilkinson, Sandra E.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 1 p. 177 - 184