1: 84 percent / PhICl2 / CH2Cl2 / 0.75 h / 10 - 15 °C / Irradiation 2: 95 percent / 15percent KOH / methanol; dioxane / 1.5 h / Heating 3: 83 percent / benzene; diethyl ether / 1 h / 20 - 25 °C 4: 88 percent / Jones reagent / acetone / 0.33 h / 0 - 5 °C View Scheme
参考文献
Davitishvili, M. G.; Karpenko, R. G.; Malyutina, O. F.; Alekseeva, L. N.; Grinenko, G. S.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 9 p. 716 - 720
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 9 p. 1121 - 1125
1: 84 percent / PhICl2 / CH2Cl2 / 0.75 h / 10 - 15 °C / Irradiation
2: 95 percent / 15percent KOH / methanol; dioxane / 1.5 h / Heating
3: 83 percent / benzene; diethyl ether / 1 h / 20 - 25 °C
4: 88 percent / Jones reagent / acetone / 0.33 h / 0 - 5 °C
5: 1.) 10percent aq. HClO4, dibromantin, 2.) 10percent NaOH / 1.) acetone, 20 min, 2.) MeOH, 0-5 deg C, 1.5 h
6: HF, pyridine / 1 h / -78 °C
7: 72 percent / 15percent KOH / methanol; dioxane / 1.5 h / Heating
View Scheme
参考文献
Davitishvili, M. G.; Karpenko, R. G.; Malyutina, O. F.; Alekseeva, L. N.; Grinenko, G. S.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 9 p. 716 - 720
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 9 p. 1121 - 1125
1: 84 percent / PhICl2 / CH2Cl2 / 0.75 h / 10 - 15 °C / Irradiation
2: 95 percent / 15percent KOH / methanol; dioxane / 1.5 h / Heating
3: 83 percent / benzene; diethyl ether / 1 h / 20 - 25 °C
4: 88 percent / Jones reagent / acetone / 0.33 h / 0 - 5 °C
5: 1.) 10percent aq. HClO4, dibromantin, 2.) 10percent NaOH / 1.) acetone, 20 min, 2.) MeOH, 0-5 deg C, 1.5 h
6: HF, pyridine / 1 h / -78 °C
View Scheme
参考文献
Davitishvili, M. G.; Karpenko, R. G.; Malyutina, O. F.; Alekseeva, L. N.; Grinenko, G. S.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 9 p. 716 - 720
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 9 p. 1121 - 1125
With iodobenzene dichloride in dichloromethane T=10 - 15°C; 0.75 h; Irradiation;
参考文献
Davitishvili, M. G.; Karpenko, R. G.; Malyutina, O. F.; Alekseeva, L. N.; Grinenko, G. S. Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 9 p. 716 - 720Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 9 p. 1121 - 1125
Multi-step reaction with 2 steps 1: 84 percent / PhICl2 / CH2Cl2 / 0.75 h / 10 - 15 °C / Irradiation2: 90 percent / pyridine, silica gel / CH2Cl2 / 3 h / 30 - 35 °C
参考文献
Davitishvili, M. G.; Karpenko, R. G.; Malyutina, O. F.; Alekseeva, L. N.; Grinenko, G. S. Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 9 p. 716 - 720Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 9 p. 1121 - 1125
