5,6-二甲氧基-2-(4-哌啶基)亚甲基-1-茚酮合成路线 （共 14 条）
反应条件
hydrogen; platinum(IV) oxide in methanol; acetic acid T=20°C; P=2311.54 Torr; 6 h;
参考文献
USV Limited, BSD MARG.
Patent: US6649765 B1, 2003 ;
Location in patent: Page/Page column 3 ;
反应条件
ammonium formate; palladium 10 on activated carbon in methanol T=20°C; 3 h; Heating / reflux;
参考文献
Reviva Pharmaceuticals, Inc.
Patent: US2008/153878 A1, 2008 ;
Location in patent: Page/Page column 13; 20 ;
反应条件
hydrogen; palladium 10 on activated carbon in tetrahydrofuran T=0 - 2°C; P=760.051 Torr; 1.5 h;
参考文献
US2007/88055 A1, ;
Page/Page column 5 ;
反应条件
hydrogen; acetic acid; palladium 10 on activated carbon in methanol T=68 - 72°C; P=3800.26 Torr; 7 h;
参考文献
US2008/306271 A1, ;
Page/Page column 8-9 ;
反应条件
1: With hydrogenchloride in ethyl acetate 2: With sodium carbonate in water; ethyl acetate pH=~ 6;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2010/143505 A1, 2010 ;
Location in patent: Page/Page column 18 ;
反应条件
1: With hydrogen; 5 Pd on alumina in tetrahydrofuran T=3 - 6°C; P=3000.3 - 7500.75 Torr; 3 - 5 h; 2: With hydrogenchloride in tetrahydrofuran; ethanol; water Product distribution / selectivity;
参考文献
US2007/88055 A1, ;
Page/Page column 4 - 5 ;
参考文献
DR. REDDY'S LABORATORIES LIMITED; DR. REDDY'S LABORATORIES, INC.
Patent: US2004/143121 A1, 2004 ;
Location in patent: Page 3 ;
反应条件
hydrogen; acetic acid; palladium on activated charcoal in methanol T=60 - 65°C; 7 h;
参考文献
Elati, Chandrashekar R.; Kolla, Naveenkumar; Chalamala, Subrahmanyeswara Rao; Vankawala, Pravinchandra J.; Sundaram, Venkataraman; Vurimidi, Himabindu; Mathad, Vijayavitthal T.
Synthetic Communications, 2006 , vol. 36, # 2 p. 169 - 174
反应条件
1: 95.6 percent / p-toluenesulfonic acid / toluene / 6 h / Heating 2: 90 percent / hydrogen; acetic acid / palladium on activated charcoal / methanol / 7 h / 60 - 65 °C View Scheme
参考文献
Synthetic Communications, , vol. 36, # 2 p. 169 - 174
反应条件
1: 95.6 percent / p-toluenesulfonic acid / toluene / 6 h / Heating 2: 90 percent / hydrogen; acetic acid / palladium on activated charcoal / methanol / 7 h / 60 - 65 °C View Scheme
参考文献
Synthetic Communications, , vol. 36, # 2 p. 169 - 174
