2-氨基-6-溴吡啶并[2,3-d]嘧啶-4(3H)-酮合成路线 （共 7 条）
反应条件
hydrogen bromide in ethanol; water; isopropyl alcohol T=78°C; Heating / reflux;
参考文献
AGOURON PHARMACEUTICALS, MINC.
Patent: US2005/85492 A1, 2005 ;
Location in patent: Page/Page column 25 ;
反应条件
hydrogen bromide; acetic acid in ethanol 72 h; Heating;
参考文献
Tomsho, John W.; McGuire, John J.; Coward, James K.
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 18 p. 3388 - 3398
反应条件
sodium hydroxide in methanol; water 12 h; Heating;
参考文献
Taylor, Edward C.; Otiv, S. R.; Durucasu, Inci
Heterocycles, 1993 , vol. 36, # 8 p. 1883 - 1895
反应条件
hydrogenchloride 24 h; Heating;
参考文献
Taylor, Edward C.; Yoon, Cheol-min
Synthetic Communications, 1988 , vol. 18, # 11 p. 1187 - 1192
反应条件
1: 93 percent / p-chlorophenylphosphoro-dichloridate, pyridine / 24 h / Ambient temperature 2: 85 percent / Na / 0.25 h / Ambient temperature 3: 83 percent / NaOH / methanol; H2O / 12 h / Heating View Scheme
参考文献
Heterocycles, , vol. 36, # 8 p. 1883 - 1895
反应条件
1: 85 percent / Na / 0.25 h / Ambient temperature 2: 83 percent / NaOH / methanol; H2O / 12 h / Heating View Scheme
参考文献
Heterocycles, , vol. 36, # 8 p. 1883 - 1895
反应条件
1: 81 percent / pyridine / 6 h / Heating
2: 87 percent / Et3N, palladium acetate, cuprous iodide, tri-o-tolylphosphine / acetonitrile / 24 h / Heating
3: 78 percent / O3 / CH2Cl2; methanol / -78 °C
4: HCl / ethanol / 4 h / 70 °C
View Scheme
参考文献
Taylor, Edward C.; Yoon, Cheol-min
Synthetic Communications, 1988 , vol. 18, # 11 p. 1187 - 1192
