1: 95 percent / NEt3 / ethanol / 24 h / Ambient temperature 2: 90 percent / H2 / 10percent Pd/C / dioxane; methanol / 760 Torr / Ambient temperature 3: 51 percent / KH2PO4, (KSO3)2NO / methanol; H2O / 4 h 4: 35 percent / 4.5 h / 0 °C View Scheme

1: 97 percent / triethylamine / ethanol / 24 h / Ambient temperature 2: trifluoroacetic acid / 5 h / Heating 3: 49 percent / potassium nitrosodisulfonate, monobasic potassium phosphate / methanol; H2O / 6 h 4: 7 percent / methanol / 9 h / 0 °C View Scheme

1: 95 percent / NEt3 / ethanol / 24 h / Ambient temperature 2: 90 percent / H2 / 10percent Pd/C / dioxane; methanol / 760 Torr / Ambient temperature 3: 51 percent / KH2PO4, (KSO3)2NO / methanol; H2O / 4 h View Scheme

Multi-step reaction with 3 steps 1: 97 percent / triethylamine / ethanol / 24 h / Ambient temperature2: trifluoroacetic acid / 5 h / Heating3: 49 percent / potassium nitrosodisulfonate, monobasic potassium phosphate / methanol; H2O / 6 h  

Multi-step reaction with 2 steps 1: 97 percent / triethylamine / ethanol / 24 h / Ambient temperature2: trifluoroacetic acid / 5 h / Heating