反式-2,4-二氯苯乙烯酸合成路线 （共 15 条）
参考文献
Walling; Wolfstirn
Journal of the American Chemical Society, 1947 , vol. 69, p. 852
反应条件
1: H2 / platinum oxide / aq. ethanol 2: oxalyl chloride / CH2Cl2 / 20 °C 3: aluminum chloride / CH2Cl2 / Heating View Scheme
参考文献
Musso, David L.; Orr, G. Faye; Cochran, Felicia R.; Kelley, James L.; Selph, Jeffrey L.; Rigdon, Greg C.; Cooper, Barrett R.; Jones, Michael L.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 3 p. 409 - 416
反应条件
1: thionyl chloride, pyridine / 40 °C 2: sodium borohydride / dioxane / Ambient temperature View Scheme
参考文献
Rideout, Janet L.; Krenitsky, Thomas A.; Chao, Esther Y.; Elion, Gertrude B.; Williams, Raymond B.; Latter, Victoria S.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1489 - 1494
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
Kotake, Tomoya; Hayashi, Yoshio; Rajesh; Mukai, Yoshie; Takiguchi, Yuka; Kimura, Tooru; Kiso, Yoshiaki
Tetrahedron, 2005 , vol. 61, # 15 p. 3819 - 3833
反应条件
1: chloroform / 20 - 60 °C / Irradiation; Bromination
2: potassium carbonate / dimethyl sulfoxide / 12 h / 115 °C
View Scheme
参考文献
Cheng, Xuezhi; Jia, Jun; Kuang, Chunxiang
Chinese Journal of Chemistry, 2011 , vol. 29, # 11 p. 2350 - 2354
