2,5-二氟-4-硝基苯酚合成路线 （共 2 条）
反应条件
nitric acid in water T=0 - 20°C; 0.5 h;
参考文献
ZENOBIA THERAPEUTICS, INC.; BOUNAUD, Pierre-Yves; NIENABER, Vicki; STEENSMA, Ruo, W.; LOWE, John, A., III
Patent: WO2012/178015 A2, 2012 ;
Location in patent: Page/Page column 137 ;
WO 2012/178015 A2
反应条件
1: 2.5-difluoro-4-nitrophenol With 18-crown-6 ether; potassium carbonate in butanone
T=20°C; 0.5 h;
2: methyl iodide in butanone
T=40°C; 168 h;
参考文献
Siena Biotech S.p.A.; Varrone, Maurizio; Travagli, Massimiliano; Minetto, Giacomo; Cesari, Lucia; Galeazzi, Simone; Caricasole, Andrea; Chiumiento, Antonio; Salerno, Massimiliano
Patent: US2014/5164 A1, 2014 ;
Location in patent: Paragraph 0211-0214 ;
