3-乙酰氨基-4-乙氧基苯甲酸甲酯合成路线 （共 7 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=60°C; 6 h; Large scale reaction;
参考文献
Mao, Yongjun; Liu, Zheng; Yang, Xiaojun; Xia, Xiangfei; Zhang, Rongxia; Li, Jianfeng; Jiang, Xiangrui; Xie, Kai; Zheng, Jin; Zhang, Hui; Suo, Jin; Shen, Jingshan
Organic Process Research and Development, 2012 , vol. 16, # 12 p. 1970 - 1973
反应条件
1: acetic acid / 3 h / 60 °C / Large scale reaction 2: potassium carbonate / N,N-dimethyl-formamide / 6 h / 60 °C / Large scale reaction View Scheme
参考文献
Mao, Yongjun; Liu, Zheng; Yang, Xiaojun; Xia, Xiangfei; Zhang, Rongxia; Li, Jianfeng; Jiang, Xiangrui; Xie, Kai; Zheng, Jin; Zhang, Hui; Suo, Jin; Shen, Jingshan
Organic Process Research and Development, 2012 , vol. 16, # 12 p. 1970 - 1973
反应条件
1: sulfuryl dichloride / 8 h / 5 - 65 °C / Large scale reaction 2: acetic acid / 3 h / 60 °C / Large scale reaction 3: potassium carbonate / N,N-dimethyl-formamide / 6 h / 60 °C / Large scale reaction View Scheme
参考文献
Zhang, Qiang; Mao, Yongjun; Liu, Zheng; Xie, Kai; Zhu, Yi; Wei, Yabing; Jiang, Xiangrui; Shen, Jingshan
Heterocycles, 2011 , vol. 83, # 12 p. 2851 - 2856
反应条件
1.1: nitric acid / nitromethane / 3 h / 20 - 30 °C 2.1: hydrogen / Raney-Ni / tetrahydrofuran; methanol / 3 h 3.1: water / trifluoroacetic acid / 12 h / 20 °C 3.2: 20 °C 4.1: ethanol; sodium / 1.5 h / 75 °C 4.2: 50 °C / pH 6 - 7 5.1: trichlorophosphate / diethylene glycol dimethyl ether / 4 - 4.5 h / 85 °C View Scheme
参考文献
Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Topharman Shangai Co., Ltd.
Patent: US2011/263860 A1, 2011 ;
反应条件
nitric acid in nitromethane T=20 - 30°C; 3 h; Product distribution / selectivity;
参考文献
Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Topharman Shangai Co., Ltd.
Patent: US2011/263860 A1, 2011 ;
Location in patent: Page/Page column 4-5 ;
反应条件
1: nitric acid / nitromethane / 3 h / 20 - 30 °C 2: hydrogen / Raney-Ni / tetrahydrofuran; methanol / 3 h View Scheme
参考文献
Mao, Yongjun; Liu, Zheng; Yang, Xiaojun; Xia, Xiangfei; Zhang, Rongxia; Li, Jianfeng; Jiang, Xiangrui; Xie, Kai; Zheng, Jin; Zhang, Hui; Suo, Jin; Shen, Jingshan
Organic Process Research and Development, 2012 , vol. 16, # 12 p. 1970 - 1973
反应条件
1.1: nitric acid / nitromethane / 3 h / 20 - 30 °C
2.1: hydrogen / Raney-Ni / tetrahydrofuran; methanol / 3 h
3.1: water / trifluoroacetic acid / 12 h / 20 °C
3.2: 20 °C
4.1: ethanol; sodium / 1.5 h / 75 °C
4.2: 50 °C / pH 6 - 7
View Scheme
参考文献
Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Topharman Shangai Co., Ltd.
Patent: US2011/263860 A1, 2011 ;
