nitric acid in nitromethane T=20 - 30°C; 3 h; Product distribution / selectivity;

1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 60 °C / |Large scale 2: nitric acid / nitromethane / 8 h / 20 - 35 °C / |Large scale View Scheme

1: acetic acid / 3.5 h / 60 °C / |Large scale 2: potassium carbonate / N,N-dimethyl-formamide / 7 h / 60 °C / |Large scale 3: nitric acid / nitromethane / 8 h / 20 - 35 °C / |Large scale View Scheme

1.1: hydrogen / Raney-Ni / tetrahydrofuran; methanol / 3 h 2.1: water / trifluoroacetic acid / 12 h / 20 °C 2.2: 20 °C 3.1: ethanol; sodium / 1.5 h / 75 °C 3.2: 50 °C / pH 6 - 7 4.1: trichlorophosphate / diethylene glycol dimethyl ether / 4 - 4.5 h / 85 °C View Scheme

hydrogen; Raney-Ni in tetrahydrofuran; methanol 3 h;

1.1: hydrogen / Raney-Ni / tetrahydrofuran; methanol / 3 h 2.1: water / trifluoroacetic acid / 12 h / 20 °C 2.2: 20 °C 3.1: ethanol; sodium / 1.5 h / 75 °C 3.2: 50 °C / pH 6 - 7 View Scheme