1: With sodium azide; acetic acid; triethylamine
T=60 - 130°C; 7 h; Inert atmosphere;
2: With sodium hydroxide in water
T=80°C; 0.25 h; Inert atmosphere; SolventReagent/catalyst;
参考文献
Bridge, Andrew W.; Jones, Ronald H.; Kabir, Humayun; Kee, Alex A.; Lythgoe, David J.; Nakach, Mustafa; Pemberton, Clive; Wrightman, John A.
Organic Process Research and Development, 2001 , vol. 5, # 1 p. 9 - 15
1: 1.) NaH / 2.) THF, reflux, 48 h
2: 72 percent / Adogen phase-transfer catalyst / toluene; H2O / 48 h / Heating
3: 66 percent / sodium azide, NH4Cl / dimethylformamide / 16 h / 110 °C
View Scheme
参考文献
Huang, Fu-Chih; Galemmo, Robert A.; Johnson, William H.; Poli, Gregory B.; Morrissette, Matthew M.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 4 p. 1194 - 1200
Huang, Fu-Chih; Galemmo, Robert A.; Johnson, William H.; Poli, Gregory B.; Morrissette, Matthew M.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 4 p. 1194 - 1200
