N-(2-氨基乙基)-N-[2-[[(1,1-二甲基乙氧基)羰基]氨基]乙基]-氨基甲酸叔丁酯合成路线 （共 6 条）
反应条件
hydrazine hydrate in methanol 12 h; Heating;
参考文献
Nagarajan, Muthukaman; Xiao, Xiangshu; Antony, Smitha; Kohlhagen, Glenda; Pommier, Yves; Cushman, Mark
Journal of Medicinal Chemistry, 2003 , vol. 46, # 26 p. 5712 - 5724
反应条件
pyridine; [bis(acetoxy)iodo]benzene; water in N,N-dimethyl-formamide T=20°C; Hofmann rearrangement;
参考文献
Andruszkiewicz, Ryszard; Gronek, Ewa; Haluszczak, Jolanta
Synthetic Communications, 2008 , vol. 38, # 6 p. 905 - 913
反应条件
tri-n-butyl-tin hydride; trifluoroacetic acid in dichloromethane Substitution;
参考文献
Verheijen, Jeroen C.; Deiman, Birgit A.L.M.; Yeheskiely, Esther; Van Der Marel, Gijs A.; Van Boom, Jacques H.
Angewandte Chemie (International Edition in English), 2000 , vol. 39, # 2 p. X369-372
反应条件
1: 16.0 g / Et3N / CHCl3 / 8 h / 23 °C 2: 82 percent / diethyl azodicarboxylate; PPh3 / tetrahydrofuran / 5 h / 20 °C 3: 72 percent / hydrazine hydrate / methanol / 12 h / Heating View Scheme
参考文献
Verheijen, Jeroen C.; Deiman, Birgit A.L.M.; Yeheskiely, Esther; Van Der Marel, Gijs A.; Van Boom, Jacques H.
Angewandte Chemie (International Edition in English), 2000 , vol. 39, # 2 p. X369-372
反应条件
1: 82 percent / diethyl azodicarboxylate; PPh3 / tetrahydrofuran / 5 h / 20 °C 2: 72 percent / hydrazine hydrate / methanol / 12 h / Heating View Scheme
参考文献
Nagarajan, Muthukaman; Xiao, Xiangshu; Antony, Smitha; Kohlhagen, Glenda; Pommier, Yves; Cushman, Mark
Journal of Medicinal Chemistry, 2003 , vol. 46, # 26 p. 5712 - 5724
反应条件
1: N1-(2-Amino-ethyl)-ethane-1,2-diamine With ethyl-α,α,α-trifluoroacetate in dichloromethane 2: di-tert-butyl dicarbonate in dichloromethane 3: With potassium carbonate in methanol; water
参考文献
Weiss, Stefan; Keller, Max; Bernhardt, Guenther; Buschauer, Armin; Koenig, Burkhard
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 17 p. 6292 - 6304
