4-(N-叔丁氧基羰基氨基甲基)苯甲酸甲酯合成路线 （共 18 条）
反应条件
triethylamine in 1,4-dioxane; water
6 h; Ambient temperature;
参考文献
Tanaka, Ken-Ichi; Yoshifuji, Shigeyuki; Nitta, Yoshihiro
Chemical & Pharmaceutical Bulletin, 1988 , vol. 36, # 8 p. 3125 - 3129
反应条件
in diethyl ether
0.5 h;
参考文献
Eli Lilly and Company; Wayne State University; University of Hawaii
Patent: US6680311 B1, 2004 ;
Location in patent: Page/Page column 151 ;
反应条件
1: With cesium fluoride in N,N-dimethyl-formamide
T=100°C; P=7500.75 Torr; 3 h; Autoclave;
2: With hydrogenchloride in diethyl ether; water; N,N-dimethyl-formamide
T=0°C; pH=2; Inert atmosphere;
参考文献
Mita, Tsuyoshi; Sugawara, Masumi; Hasegawa, Hiroyuki; Sato, Yoshihiro
Journal of Organic Chemistry, 2012 , vol. 77, # 5 p. 2159 - 2168
反应条件
1: carbon dioxide; C26H45NO4Sn With cesium fluoride in N,N-dimethyl-formamide
T=100°C; P=7500.75 Torr; 3 h; Autoclave;
2: With hydrogenchloride in diethyl ether; water; N,N-dimethyl-formamide
T=0°C; pH=2; Inert atmosphere;
3: diazomethyl-trimethyl-silane in methanol; diethyl ether
1 h; Inert atmosphere;
参考文献
Mita, Tsuyoshi; Sugawara, Masumi; Hasegawa, Hiroyuki; Sato, Yoshihiro
Journal of Organic Chemistry, 2012 , vol. 77, # 5 p. 2159 - 2168
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1104754 A1, 2001 ;
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide
参考文献
Tamura; Matsushita; Iwama; Harada; Kishimoto; Itoh
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 5 p. 1199 - 1212
反应条件
1: 92 percent / ruthenium dioxide hydrate, 10percent aqueous NaIO4 / ethyl acetate / 2 h / Ambient temperature
2: 95 percent / trifluoroacetic acid / CH2Cl2 / 1 h / Ambient temperature
View Scheme
参考文献
Tanaka, Ken-Ichi; Yoshifuji, Shigeyuki; Nitta, Yoshihiro
Chemical & Pharmaceutical Bulletin, 1988 , vol. 36, # 8 p. 3125 - 3129
反应条件
1: 93 percent / LiAlH4 / tetrahydrofuran / 5 h / 0 °C
2: 78 percent / 4-dimethylaminopyridine / CH2Cl2 / 14 h / 0 - 20 °C
View Scheme
参考文献
Gutierrez-Nava, Manuel; Nierengarten, Helene; Masson, Patrick; Van Dorsselaer, Alain; Nierengarten, Jean-Francois
Tetrahedron Letters, 2003 , vol. 44, # 15 p. 3043 - 3046
