5-溴-n-异丙基吡啶-3-胺合成路线 （共 3 条）
反应条件
copper(l) iodide; potassium acetate; L-proline in N,N-dimethyl-formamide T=85°C; 12 h; Inert atmosphere;
参考文献
PROGENICS PHARMACEUTICALS, INC.
Patent: WO2009/155527 A2, 2009 ;
Location in patent: Page/Page column 128 ;
WO 2009/155527 A2
反应条件
1: With acetic acid in methanol pH=4; 0.5 h; 2: With methanol; sodium cyanoborohydride T=20°C;
参考文献
Samumed, LLC; Hood, John; Wallace, David Mark; Kumar KC, Sunil
Patent: US2013/267495 A1, 2013 ;
Location in patent: Paragraph 0444-0445 ;
反应条件
in 1-methyl-pyrrolidin-2-one T=190°C; 10.5 h; Inert atmosphere;
参考文献
NOVARTIS AG; FURET, Pascal; IMBACH, Patricia; MAH, Robert; STAUFFER, Frederic
Patent: WO2010/139747 A1, 2010 ;
Location in patent: Page/Page column 123-124 ;
WO 2010/139747 A1
