6-氯-3-甲基吡啶-2-甲酸合成路线 （共 5 条）
反应条件
water; sodium hydroxide in tetrahydrofuran; methanol T=20°C; 3 h;
参考文献
ELI LILLY AND COMPANY; BLANCO-PILLADO, Maria-Jesus; VETMAN, Tatiana Natali; FISHER, Matthew Joseph; KUKLISH, Steven Lee
Patent: WO2014/4230 A1, 2014 ;
Location in patent: Page/Page column 8; 45 ;
反应条件
1: With water; potassium hydroxide Reflux; 2: With hydrogenchloride in water T=20°C;
参考文献
WO2009/155156 A1, ;
Page/Page column 63 ;
WO 2009/155156 A1
反应条件
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C 2.1: trichlorophosphate / 6 h / Reflux 3.1: potassium hydroxide; water / Reflux 3.2: 20 °C View Scheme
参考文献
WO2009/155156 A1, ;
WO 2009/155156 A1
反应条件
1.1: trichlorophosphate / 6 h / Reflux 2.1: potassium hydroxide; water / Reflux 2.2: 20 °C View Scheme
参考文献
WO2009/155156 A1, ;
WO 2009/155156 A1
反应条件
methanol in tetrahydrofuran T=20°C; 2 h;
参考文献
MERCK and CO., INC.
Patent: WO2009/155156 A1, 2009 ;
Location in patent: Page/Page column 63 ;
WO 2009/155156 A1
