1-(1-甲基-4-哌啶基)-1H-吡唑-4-胺合成路线 (共 3 条)
反应条件
hydrogen; palladium on activated charcoal in ethanol T=25°C; P=760.051 Torr; 16 h; Inert atmosphere;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/153589 A1, 2009 ;
Location in patent: Page/Page column 109 ;
WO 2009/153589 A1
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=60°C; 16 h;
参考文献
ONCOTHERAPY SCIENCE, INC.; MATSUO, Yo; HISADA, Shoji; NAKAMURA, Yusuke; AHMED, Feryan; WALKER, Joel R.; HUNTLEY, Raymond
Patent: WO2013/109388 A2, 2013 ;
Location in patent: Page/Page column 156 ;
反应条件
1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h / 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 60 °C View Scheme
参考文献
ONCOTHERAPY SCIENCE, INC.; MATSUO, Yo; HISADA, Shoji; NAKAMURA, Yusuke; AHMED, Feryan; WALKER, Joel R.; HUNTLEY, Raymond
Patent: WO2013/109388 A2, 2013 ;