反应条件
1: ortho-bromobenzaldehyde; immobilized on REM resin N-CBz-α-phosphonylglycine With 1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran T=20°C; Horner-Emmons reaction; 12 h; 2: With tri-tert-butyl phosphine; N,N-dicyclohexylmethylamine; tris(dibenzylideneacetone)dipalladium(0) chloroform complex in toluene T=80°C; 3: methanol With sodium methylate in tetrahydrofuran T=20°C; 12 h; Further stages.;
