((2R,3R)-3-((S)-1-(tert丁氧基羰基)吡咯烷-2-基)-3-甲氧基-2-甲基丙酸合成路线 （共 30 条）
反应条件
sodium hydride in tetrahydrofuran T=0°C; 18 h;
参考文献
Shioiri, Takayuki; Hayashi, Kyoko; Hamada, Yasumasa
Tetrahedron, 1993 , vol. 49, # 9 p. 1913 - 1924
反应条件
ruthenium(IV) oxide; sodium periodate in tetrachloromethane; water; acetonitrile 48 h;
参考文献
Roux, Florence; Maugras, Isabelle; Poncet, Joel; Niel, Gilles; Jouin, Patrick
Tetrahedron, 1994 , vol. 50, # 18 p. 5345 - 5360
反应条件
1: DABCO / CH2Cl2 / 120 h / 20 °C / ultrasound 2: H2 / Pd/C / ethyl acetate / 20 °C 3: 70 percent / proton sponge / CH2Cl2 / 18 h / 20 °C 4: 86 percent / LiOH / tetrahydrofuran; H2O / 16 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 5 p. 937 - 940
反应条件
1: With lithium hydroxide; dihydrogen peroxide in tetrahydrofuran T=0°C; 3 h; 2: With sodium sulfite in tetrahydrofuran T=0 - 20°C; 18 h; Further stages.;
参考文献
Pettit; Grealish
Journal of Organic Chemistry, 2001 , vol. 66, # 25 p. 8640 - 8642
反应条件
hydrogen; palladium on activated charcoal in methanol 12 h; Ambient temperature;
参考文献
Pettit, George R.; Singh, Sheo Bux; Herald, Delbert L.; Lloyd-Williams, Paul; Kantoci, Darko; et al.
Journal of Organic Chemistry, 1994 , vol. 59, # 21 p. 6287 - 6295
反应条件
lithium hydroxide in ethanol
参考文献
Tomioka, Kiyoshi; Kanai, Motomu; Koga, Kenji
Tetrahedron Letters, 1991 , vol. 32, # 21 p. 2395 - 2398
反应条件
lithium hydroxide in tetrahydrofuran; water T=20°C; 16 h;
参考文献
Almeida, Wanda P.; Coelho, Fernando
Tetrahedron Letters, 2003 , vol. 44, # 5 p. 937 - 940
反应条件
1: BF3*Et2O 2: 57 percent / potassium tert-butoxide / tetrahydrofuran / -20 °C 3: H2 / Pd/C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 111, # 14 p. 5463 - 5465
反应条件
1: 57 percent / potassium tert-butoxide / tetrahydrofuran / -20 °C 2: H2 / Pd/C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 111, # 14 p. 5463 - 5465
反应条件
sodium periodate; osmium(VIII) oxide in water; ethyl acetate; acetonitrile; tert-butyl alcohol
参考文献
US2013/129753 A1, ;
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