((2R,3R)-3-((S)-1-(tert丁氧基羰基)吡咯烷-2-基)-3-甲氧基-2-甲基丙酸合成路线 （共 30 条）
反应条件
1: H2 / Pd/C / ethyl acetate / 20 °C 2: 70 percent / proton sponge / CH2Cl2 / 18 h / 20 °C 3: 86 percent / LiOH / tetrahydrofuran; H2O / 16 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 5 p. 937 - 940
反应条件
1: 41 percent / BF3*OEt2 / CH2Cl2 2: H2 / 5percent Pd/C / 2-methyl-propan-2-ol; H2O View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 43, # 10 p. 1706 - 1718
反应条件
hydrogen; palladium on activated charcoal in water; tert-butyl alcohol
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 43, # 10 p. 1706 - 1718
反应条件
1: 45 percent / LHMDS; HMPA / tetrahydrofuran / 0.25 h / -20 °C 2: 59 percent / LiOH*H2O / ethanol; H2O / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 60, # 43 SPEC. ISS. p. 9715 - 9723
反应条件
1: 90 percent / NaH / dimethylformamide / 24 h / Ambient temperature 2: NaIO4, 60 percent aq. RuO2 / acetonitrile; CCl4 / 6 h 3: 1 M KMnO4 / 2-methyl-propan-2-ol / 0.25 h View Scheme
参考文献
Tetrahedron, , vol. 50, # 18 p. 5345 - 5360
反应条件
1: 70 percent / proton sponge / CH2Cl2 / 18 h / 20 °C 2: 86 percent / LiOH / tetrahydrofuran; H2O / 16 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 5 p. 937 - 940
反应条件
1: 89 percent / AlLiH4 / tetrahydrofuran / 1 h / Ambient temperature 2: 72 percent / tetrahydrofuran / 3 h / Ambient temperature 3: 90 percent / NaH / dimethylformamide / 24 h / Ambient temperature 4: NaIO4, 60 percent aq. RuO2 / acetonitrile; CCl4 / 6 h 5: 1 M KMnO4 / 2-methyl-propan-2-ol / 0.25 h View Scheme
参考文献
Tetrahedron, , vol. 50, # 18 p. 5345 - 5360
反应条件
1: 1) LDA / 1) THF, HMPA, -78 deg C, 2) -78 deg C to -20 deg C, 2.5 h 2: 1) LDA, 2) MeOH / 1) THF, -20 deg C, 1 h, 2) -78 deg C 3: 1) LHMDS / 1) THF, HMPA 4: 91 percent / aq.LiOH / ethanol View Scheme
参考文献
Tetrahedron Letters, , vol. 32, # 21 p. 2395 - 2398
反应条件
1: 1) LDA, 2) MeOH / 1) THF, -20 deg C, 1 h, 2) -78 deg C 2: 1) LHMDS / 1) THF, HMPA 3: 91 percent / aq.LiOH / ethanol View Scheme
参考文献
Tetrahedron Letters, , vol. 32, # 21 p. 2395 - 2398
反应条件
1: 88 percent / K2CO3 2: 1) LHMDS / 1) THF, HMPA 3: 91 percent / aq.LiOH / ethanol View Scheme
参考文献
Tetrahedron Letters, , vol. 32, # 21 p. 2395 - 2398
