5-(6-氯-1-甲基-吲哚-2-基)烟醛合成路线 （共 3 条）
反应条件
sodium hydride in N,N-dimethyl-formamide T=0°C; 2 h;
参考文献
NOVARTIS AG
Patent: WO2009/156462 A2, 2009 ;
Location in patent: Page/Page column 144 ;
反应条件
1.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; potassium phosphate / tris-(dibenzylideneacetone)dipalladium(0) / toluene / 1.5 h / 85 °C / Inert atmosphere 1.2: 63 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 °C View Scheme
参考文献
NOVARTIS AG
Patent: WO2009/156462 A2, 2009 ;
反应条件
1.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; potassium phosphate / tris-(dibenzylideneacetone)dipalladium(0) / toluene / 1.5 h / 85 °C / Inert atmosphere 1.2: 63 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 °C View Scheme
参考文献
NOVARTIS AG
Patent: WO2009/156462 A2, 2009 ;
