4-(羟基甲基)-1H-咪唑-1-羧酸叔丁酯合成路线 （共 6 条）
反应条件
triethylamine in tetrahydrofuran; N,N-dimethyl-formamide T=0 - 20°C;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: US2009/170907 A1, 2009 ;
Location in patent: Page/Page column 45 ;
反应条件
4-(N,N-dimethlyamino)pyridine; sodium carbonate in tetrahydrofuran; water
参考文献
Zeneca Limited
Patent: US5521179 A1, 1996 ;
反应条件
in N,N-dimethyl-formamide
参考文献
Peng, Hairuo; Carrico, Dora; Thai, Van; Blaskovich, Michelle; Bucher, Cynthia; Pusateri, Erin E.; Sebti, Said M.; Hamilton, Andrew D.
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 9 p. 1768 - 1784
反应条件
oxalyl dichloride; dimethyl sulfoxide in dichloromethane
T=-78°C; 0.25 h;
参考文献
Kimura, Rumi; Nagano, Tanemasa; Kinoshita, Hideki
Bulletin of the Chemical Society of Japan, 2002 , vol. 75, # 11 p. 2517 - 2525
反应条件
1: With thionyl chloride; N,N-dimethyl-formamide in dichloromethane
T=0°C;
2: With sodium hydrogencarbonate in water; ethyl acetate
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: US2009/170907 A1, 2009 ;
Location in patent: Page/Page column 45-46 ;
反应条件
thionyl chloride in dichloromethane; N,N-dimethyl-formamide
T=0°C; 0.25 h;
参考文献
Peng, Hairuo; Carrico, Dora; Thai, Van; Blaskovich, Michelle; Bucher, Cynthia; Pusateri, Erin E.; Sebti, Said M.; Hamilton, Andrew D.
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 9 p. 1768 - 1784
