4-氨基哌啶-1-甲酸苄酯合成路线 （共 3 条）
反应条件
1: With hydrogenchloride in tetrahydrofuran; water T=30 - 55°C; 2: With sodium hydroxide in tetrahydrofuran; dichloromethane; water T=10 - 25°C;
参考文献
MERCK and CO., INC.
Patent: WO2009/91856 A2, 2009 ;
Location in patent: Page/Page column 63-64 ;
WO 2009/091856 A2
反应条件
hydrazine in ethanol 0.5 h; Heating / reflux;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/150011 A2, 2007 ;
Location in patent: Page/Page column 105 ;
反应条件
1: in tetrahydrofuran
T=20°C; 1 h;
2: With lithium hexamethyldisilazane in tetrahydrofuran
16 h;
3: With hydrogenchloride in dichloromethane; water
参考文献
Faull, Alan; Tucker, Howard
Patent: US2007/167442 A1, 2007 ;
Location in patent: Page/Page column 44 ;
