5,6-二氢-6-甲基-4H-噻吩并[2,3-b]噻喃-4-酮合成路线 (共 3 条)
反应条件
1: With oxalyl dichloride in dichloromethane; N,N-dimethyl-formamide T=20°C; 2 h; 2: With tin(ll) chloride in dichloromethane; N,N-dimethyl-formamide T=0 - 5°C;
参考文献
WO2010/61398 A1, ;
Page/Page column 19-20; 24-25 ;
反应条件
potassium carbonate in methanol; water 6 h; Reflux;
参考文献
US2009/234140 A1, ;
Page/Page column 4 ;
反应条件
sulfuric acid; propionic acid anhydride in toluene T=-5 - 30°C; 3 h; Product distribution / selectivity;
参考文献
SANDOZ AG
Patent: EP1918293 A1, 2008 ;
Location in patent: Page/Page column 4-5; 6 ;