5-溴-1,2,3,4-四氢-4,4-二甲基异喹啉合成路线 （共 4 条）
反应条件
1: With dimethylsulfide borane complex in tetrahydrofuran T=0°C; 19 h; Reflux; 2: With methanol 18 h; Reflux;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; ORWAT, Michael J.; PINTO, Donald J.P.; SMITH II, Leon M.; SRIVASTAVA, Shefali
Patent: WO2013/56034 A1, 2013 ;
Location in patent: Paragraph 003606 ;
反应条件
1.1: triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C 2.1: polyphosphoric acid / 1 h / 150 °C 3.1: dimethylsulfide borane complex / tetrahydrofuran / 19 h / 0 °C / |Reflux 3.2: 18 h / |Reflux View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; ORWAT, Michael J.; PINTO, Donald J.P.; SMITH II, Leon M.; SRIVASTAVA, Shefali
Patent: WO2013/56034 A1, 2013 ;
反应条件
1.1: dimethylsulfide borane complex / tetrahydrofuran / 19 h / 0 °C / |Reflux 2.1: triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C 3.1: polyphosphoric acid / 1 h / 150 °C 4.1: dimethylsulfide borane complex / tetrahydrofuran / 19 h / 0 °C / |Reflux 4.2: 18 h / |Reflux View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; ORWAT, Michael J.; PINTO, Donald J.P.; SMITH II, Leon M.; SRIVASTAVA, Shefali
Patent: WO2013/56034 A1, 2013 ;
反应条件
1.1: polyphosphoric acid / 1 h / 150 °C 2.1: dimethylsulfide borane complex / tetrahydrofuran / 19 h / 0 °C / |Reflux 2.2: 18 h / |Reflux View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; ORWAT, Michael J.; PINTO, Donald J.P.; SMITH II, Leon M.; SRIVASTAVA, Shefali
Patent: WO2013/56034 A1, 2013 ;
