3,3'-[[[3-[(1E)-2-(7-氯-2-喹啉基)乙烯基]苯基]亚甲基]二(硫代)]二-丙酸1,1'-二甲酯合成路线 （共 11 条）
反应条件
boron trifluoride diethyl etherate in dichloromethane T=-5 - 0°C; 2 h;
参考文献
McNamara, J. M.; Leazer, J. L.; Bhupathy, M.; Amato, J. S.; Reamer, R. A.; et al.
Journal of Organic Chemistry, 1989 , vol. 54, # 15 p. 3718 - 3721
反应条件
n-butyllithium in tetrahydrofuran; hexane; ethyl acetate
参考文献
MERCK FROSST CANADA INC.
Patent: EP233763 A2, 1987 ;
反应条件
boron trifluoride diethyl etherate in dichloromethane T=-50°C; 16 h; Title compound not separated from byproducts;
参考文献
McNamara, J. M.; Leazer, J. L.; Bhupathy, M.; Amato, J. S.; Reamer, R. A.; et al.
Journal of Organic Chemistry, 1989 , vol. 54, # 15 p. 3718 - 3721
反应条件
in hexane; acetic anhydride; ethyl acetate
参考文献
Merck Frosst Canada Inc.
Patent: US4851409 A1, 1989 ;
反应条件
1: 46 percent / NBS, benzoyl peroxide / CCl4 / 48 h / Heating; Irradiation 2: 72 percent / acetonitrile / 60 °C 3: 1.) BuLi / 1.) THF, -78 deg C, 30 min, 2.) THF, from -78 deg C to RT View Scheme
参考文献
McNamara, J. M.; Leazer, J. L.; Bhupathy, M.; Amato, J. S.; Reamer, R. A.; et al.
Journal of Organic Chemistry, 1989 , vol. 54, # 15 p. 3718 - 3721
反应条件
1: 37 percent / trimethylsilyl chloride / CHCl3 / 2 h / Ambient temperature 2: 1.) BuLi / 1.) THF, -78 deg C, 30 min, 2.) THF, from -78 deg C to RT View Scheme
参考文献
McNamara, J. M.; Leazer, J. L.; Bhupathy, M.; Amato, J. S.; Reamer, R. A.; et al.
Journal of Organic Chemistry, 1989 , vol. 54, # 15 p. 3718 - 3721
反应条件
1: 72 percent / acetonitrile / 60 °C 2: 1.) BuLi / 1.) THF, -78 deg C, 30 min, 2.) THF, from -78 deg C to RT View Scheme
参考文献
Zamboni; Belley; Champion; Charette; DeHaven; Frenette; Gauthier; Jones; Leger; Masson; McFarlane; Metters; Pong; Piechuta; Rokach; Therien; Williams; Young
Journal of Medicinal Chemistry, 1992 , vol. 35, # 21 p. 3832 - 3844
反应条件
n-butyllithium 1.) THF, -78 deg C, 30 min, 2.) THF, from -78 deg C to RT; Yield given. Multistep reaction;
参考文献
Zamboni; Belley; Champion; Charette; DeHaven; Frenette; Gauthier; Jones; Leger; Masson; McFarlane; Metters; Pong; Piechuta; Rokach; Therien; Williams; Young
Journal of Medicinal Chemistry, 1992 , vol. 35, # 21 p. 3832 - 3844
反应条件
1: Triton X-100 / hydrolysis with Pseudomonas species lipase 2: 70 percent / Me3Al View Scheme
参考文献
Hughes, D. L.; Song, Z.; Smith, G. B.; Bergan, J. J.; Dezeny, G. C.; et al.
Tetrahedron: Asymmetry, 1993 , vol. 4, # 5 p. 865 - 874
反应条件
water; Triton X-100 T=40°C; lipase, phosphate buffer, pH = 7.5; Kinetics;
参考文献
Hughes; Bergan; Amato; Reider; Grabowski
Journal of Organic Chemistry, 1989 , vol. 54, # 8 p. 1787 - 1788
