4-氯联苯-2-胺盐酸盐合成路线 （共 20 条）
反应条件
1: H2SO4; aqueous HNO3 / 65 °C 2: Raney nickel / Hydrogenation View Scheme
参考文献
Journal of the American Chemical Society, , vol. 68, p. 404
反应条件
potassium carbonate T=80°C; Suzuki Coupling; P=760.051 Torr; 12 h; Green chemistry;
参考文献
ChemCatChem, , vol. 5, # 1 p. 349 - 354
反应条件
aluminium trichloride T=20°C; 3 h;
参考文献
Journal of the Chemical Society. Perkin Transactions 1, , # 22 p. 3064 - 3068
反应条件
1: hydrogenchloride; sodium nitrite / water; acetic acid / 1 h / 0 °C 2: manganese(IV) oxide / acetonitrile / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 77, # 23 p. 10699 - 10706
反应条件
PPA; trifluoroacetic acid T=20°C; Substitution; decomposition; trifluoroacetylation; 3 h; Further byproducts. Title compound not separated from byproducts.;
参考文献
Journal of the Chemical Society. Perkin Transactions 2, , # 2 p. 295 - 300
反应条件
Cu(TFA)2*xH2O; palladium diacetate in 2,2,2-trifluoroethanol T=70°C; P=760.051 Torr; 3 h;
参考文献
Liang, Zunjun; Zhang, Jitan; Liu, Zhanxiang; Wang, Kai; Zhang, Yuhong
Tetrahedron, 2013 , vol. 69, # 31 p. 6519 - 6526
反应条件
triethylamine in tetrahydrofuran T=25°C; 1 h;
参考文献
Synlett, , # 14 art. no. S03411ST, p. 2064 - 2068
反应条件
in toluene; xylene T=10 - 95°C; P=150.015 Torr;
参考文献
US2011/54183 A1, ;
Page/Page column 4 ;
反应条件
phosphorus trichoride in acetonitrile T=150°C; 0.166667 h; Microwave irradiation;
参考文献
Advanced Synthesis and Catalysis, , vol. 352, # 17 p. 3089 - 3097
反应条件
1: With [(k2-P,N-di(1-adamantyl)-2-morpholinophenylphosphine)Pd(Ph)Cl]; sodium t-butanolate in 1,4-dioxane
Inert atmosphereGlovebox;
2: With ammonia in 1,4-dioxane
T=24°C; 36 h; Inert atmosphereGlovebox;
参考文献
Alsabeh, Pamela G.; Lundgren, Rylan J.; McDonald, Robert; Johansson Seechurn, Carin C. C.; Colacot, Thomas J.; Stradiotto, Mark
Chemistry - A European Journal, 2013 , vol. 19, # 6 p. 2131 - 2141
