N,N-双(2-氯乙基)-4-羟基苯胺合成路线 （共 5 条）
反应条件
1: 39 percent 2: 76 percent / KOH / ethanol 3: 62 percent / MsCl / pyridine 4: H2 / Pd/C / ethanol View Scheme
参考文献
Schmidt; Florent; Monneret; Straub; Czech; Gerken; Bosslet
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 8 p. 1071 - 1076
反应条件
T=37°C; 3 h; bacterial carboxypeptidase enzyme (CPG2), pH 7.4; Rate constant;
参考文献
Dowell, Robert I.; Springer, Caroline J.; Davies, David H.; Hadley, Elizabeth M.; Burke, Philip J.; Boyle, F. Thomas; Melton, Roger G.; Connors, Thomas A.; Blakey, David C.; Mauger, Anthony B.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 5 p. 1100 - 1105
反应条件
T=37°C; kinetics of cleavage with E.Coli β-glucuronidase in buffer pH 7.2; Kinetics;
参考文献
Schmidt; Florent; Monneret; Straub; Czech; Gerken; Bosslet
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 8 p. 1071 - 1076
反应条件
1: Py 2: aq. HCl / acetic acid View Scheme
参考文献
Benn,M.H. et al.
Journal of the Chemical Society, 1961 , p. 2365 - 2375
参考文献
Benn,M.H. et al.
Journal of the Chemical Society, 1961 , p. 2365 - 2375
