4-甲基-联苯-4-胺盐酸盐合成路线 （共 29 条）
反应条件
1: 71 percent / Ba(OH)2*8H2O; Pd(PPh3)4 / H2O; 1,2-dimethoxy-ethane / 80 °C 2: 90 percent / SnCl2*2H2O / ethanol; ethyl acetate / Heating View Scheme
参考文献
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, , vol. 515, # 1-2 p. 15 - 38
反应条件
1: 71 percent / Ba(OH)2*8H2O; Pd(PPh3)4 / H2O; 1,2-dimethoxy-ethane / 80 °C 2: 90 percent / SnCl2*2H2O / ethanol; ethyl acetate / Heating View Scheme
参考文献
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, , vol. 515, # 1-2 p. 15 - 38
反应条件
trifluorormethanesulfonic acid T=5°C; 0.5 h; Further byproducts given;
参考文献
Journal of the American Chemical Society, , vol. 103, # 3 p. 645 - 653
反应条件
1.1: Mg / tetrahydrofuran / Heating 1.2: trimethylborate / tetrahydrofuran; diethyl ether / 2 h / 20 °C 1.3: 85 percent / 5 percent aq. HCl / tetrahydrofuran; diethyl ether / 1 h 2.1: 71 percent / Ba(OH)2*8H2O; Pd(PPh3)4 / H2O; 1,2-dimethoxy-ethane / 80 °C 3.1: 90 percent / SnCl2*2H2O / ethanol; ethyl acetate / Heating View Scheme
参考文献
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, , vol. 515, # 1-2 p. 15 - 38
反应条件
1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / water / 0.17 h / 150 °C / Microwave irradiation 2: trifluoroacetic acid / dichloromethane / 20 °C 3: polystyrene N-methylmorpholine / dichloromethane / 6 h / 20 °C 4: 10 palladium on activated charcoal; hydrogen / ethanol; ethyl acetate / 65 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 52, # 31 p. 3963 - 3968
反应条件
1: trifluoroacetic acid / dichloromethane / 20 °C 2: polystyrene N-methylmorpholine / dichloromethane / 6 h / 20 °C 3: 10 palladium on activated charcoal; hydrogen / ethanol; ethyl acetate / 65 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 52, # 31 p. 3963 - 3968
反应条件
1: polystyrene N-methylmorpholine / dichloromethane / 6 h / 20 °C 2: 10 palladium on activated charcoal; hydrogen / ethanol; ethyl acetate / 65 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 52, # 31 p. 3963 - 3968
反应条件
PPA; trifluoroacetic acid T=50°C; Substitution; decomposition; trifluoroacetylation; 3 h; Further byproducts.;
参考文献
Journal of the Chemical Society. Perkin Transactions 2, , # 2 p. 295 - 300
反应条件
PPA; trifluoroacetic acid T=20°C; Substitution; decomposition; trifluoroacetylation; 3 h; Further byproducts. Title compound not separated from byproducts.;
参考文献
Journal of the Chemical Society. Perkin Transactions 2, , # 2 p. 295 - 300
反应条件
PPA; trifluoroacetic acid T=20°C; Substitution; decomposition; trifluoroacetylation; 3 h; Further byproducts. Title compound not separated from byproducts.;
参考文献
Journal of the Chemical Society. Perkin Transactions 2, , # 2 p. 295 - 300
