4-(2’-溴乙基)-3-氯-1,3-二氯-2-吲哚酮合成路线 （共 13 条）
反应条件
1: acetyl chloride With anhydrous iron chloride in dichloromethane T=0 - 5°C; 0.25 h; 2: 2-(2-bromoethyl)-β-nitrostyrene in dichloromethane T=5°C; 1.5 h; 3: With hydrogenchloride in dichloromethane; water 0.5 h;
参考文献
WO2005/80333 A1, ;
Page/Page column 21-22 ;
反应条件
1: 80 percent / MeONa / methanol / 1 h / 0 °C 2: 53 percent / AcCl, FeCl3 / CH2Cl2 / 3 h / 0 - 5 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 32, # 3 p. 875 - 882
反应条件
1: bromine / water / |Irradiation 2: water; methanol / |Acidic conditions; |Large scale 3: anhydrous iron chloride / |Acidic conditions; |Large scale View Scheme
参考文献
Organic Process Research and Development, , vol. 2, # 1 p. 3 - 9
反应条件
1: water; methanol / |Acidic conditions; |Large scale 2: anhydrous iron chloride / |Acidic conditions; |Large scale View Scheme
参考文献
Organic Process Research and Development, , vol. 2, # 1 p. 3 - 9
反应条件
anhydrous iron chloride Acidic conditionsLarge scale;
参考文献
Organic Process Research and Development, , vol. 2, # 1 p. 3 - 9
反应条件
1: 95 percent / aq. NaH2PO2 / 10percent Pd-C / ethyl acetate / 0.58 h / Heating 2: 89 percent / ethanol; H2O / 24 h / Heating 3: 70 percent / aq. HCl / 2.5 h / Heating 4: 80 percent / pyridine / CH2Cl2 / 5 - 10 °C 5: H2O / 2 h / Heating View Scheme
参考文献
Hayler; Howie; Giles; Negus; Oxley; Walsgrove; Walsh; Dagger; Fortunak; Mastrocola
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 3 p. 875 - 882
反应条件
1: in water; toluene Inert atmosphereReflux; 2: With sodium tetrahydroborate in water; acetonitrile 3: With hydrogenchloride in dichloromethane; water; acetonitrile T=5°C; 1 h;
参考文献
TARO PHARMACEUTICAL INDUSTRIES LTD.; PIZEM, Hillel; PELEG, Hannan; CYJON, Rosa
Patent: WO2011/30330 A2, 2011 ;
Location in patent: Page/Page column 9 ;
反应条件
1: palladium on activated charcoal; sodium hypophosphite hydrate / water; ethyl acetate / |Large scale 2: hydrogenchloride / water / |Large scale View Scheme
参考文献
Hayler, John D.; Howie, Simon L. B.; Giles, Robert G.; Negus, Alan; Oxley, Paul W.; Walsgrove, Timothy C.; Whiter
Organic Process Research and Development, 1998 , vol. 2, # 1 p. 3 - 9
反应条件
1: 95 percent / aq. NaH2PO2 / 10percent Pd-C / ethyl acetate / 0.58 h / Heating 2: 89 percent / ethanol; H2O / 24 h / Heating 3: 70 percent / aq. HCl / 2.5 h / Heating 4: 87 percent / pyridine / CH2Cl2 / 4 h / 5 - 10 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 32, # 3 p. 875 - 882
反应条件
sodium hypophosphite; palladium on activated charcoal in ethyl acetate 0.583333 h; Heating;
参考文献
Hayler, John D.; Howie, Simon L. B.; Giles, Robert G.; Negus, Alan; Oxley, Paul W.; Walsgrove, Timothy C.; Whiter
Organic Process Research and Development, 1998 , vol. 2, # 1 p. 3 - 9
