4-(2’-溴乙基)-1,3-二氯-2-吲哚酮合成路线 （共 12 条）
反应条件
sodium hypophosphite; palladium on activated charcoal in ethyl acetate 0.583333 h; Heating;
参考文献
Hayler, John D.; Howie, Simon L. B.; Giles, Robert G.; Negus, Alan; Oxley, Paul W.; Walsgrove, Timothy C.; Whiter
Organic Process Research and Development, 1998 , vol. 2, # 1 p. 3 - 9
反应条件
carbon palladium in water
参考文献
Smith Kline and French Laboratories Limited
Patent: US4997954 A1, 1991 ;
反应条件
1: 80 percent / MeONa / methanol / 1 h / 0 °C 2: 53 percent / AcCl, FeCl3 / CH2Cl2 / 3 h / 0 - 5 °C 3: 95 percent / aq. NaH2PO2 / 10percent Pd-C / ethyl acetate / 0.58 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 32, # 3 p. 875 - 882
反应条件
1: bromine / water / |Irradiation 2: water; methanol / |Acidic conditions; |Large scale 3: anhydrous iron chloride / |Acidic conditions; |Large scale 4: palladium on activated charcoal; sodium hypophosphite hydrate / water; ethyl acetate / |Large scale View Scheme
参考文献
Organic Process Research and Development, , vol. 2, # 1 p. 3 - 9
反应条件
1: water; methanol / |Acidic conditions; |Large scale 2: anhydrous iron chloride / |Acidic conditions; |Large scale 3: palladium on activated charcoal; sodium hypophosphite hydrate / water; ethyl acetate / |Large scale View Scheme
参考文献
Organic Process Research and Development, , vol. 2, # 1 p. 3 - 9
反应条件
1: 89 percent / ethanol; H2O / 24 h / Heating 2: 70 percent / aq. HCl / 2.5 h / Heating 3: 80 percent / pyridine / CH2Cl2 / 5 - 10 °C 4: H2O / 2 h / Heating View Scheme
参考文献
Hayler; Howie; Giles; Negus; Oxley; Walsgrove; Walsh; Dagger; Fortunak; Mastrocola
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 3 p. 875 - 882
反应条件
in water 2.5 h; Heating;
参考文献
Hayler; Howie; Giles; Negus; Oxley; Walsgrove; Walsh; Dagger; Fortunak; Mastrocola
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 3 p. 875 - 882
反应条件
1: in water; acetonitrile T=65 - 70°C; 1.25 h; 2: With hydrogenchloride in water pH=2;
参考文献
TORRENT PHARMACEUTICALS LTD
Patent: WO2005/80333 A1, 2005 ;
Location in patent: Page/Page column 23 ;
反应条件
hydrogenchloride in water Large scale;
参考文献
Organic Process Research and Development, , vol. 2, # 1 p. 3 - 9
