5-(二氟甲基)-1-甲基-1H-吡唑-4-甲酸合成路线 (共 4 条)
反应条件
1: in ethanol T=-15 - -5°C; 19.5 h; 2: With sodium hydroxide in ethanol; water T=50°C; 7 h; 3: With hydrogenchloride in water pH=2;
参考文献
BAYER CROPSCIENCE AKTIENGESELLSCHAFT
Patent: WO2005/3077 A1, 2005 ;
Location in patent: Page 13 ;
反应条件
1: N,N-dimethylamino-1,1,2,2-tetrafluoroethane With boron trifluoride diethyl etherate in 1,4-dioxane; diethyl ether T=0 - 5°C; Inert atmosphere; 2: ethyl 3-(pyrrolidin-1-yl)acrylate With pyridine in 1,4-dioxane; diethyl ether T=0 - 5°C; 3: methylhydrazine
参考文献
BASF SE
Patent: US2010/184994 A1, 2010 ;
Location in patent: Page/Page column 9 ;
反应条件
1: With sodium hydroxide in water; xylene T=15 - 25°C; 0.666667 h; 2: With sodium hydroxide; water in xylene T=65°C; 0.75 h; 3: With hydrogenchloride; water in xylene T=95°C; 0.166667 h; Product distribution / selectivity;
参考文献
Syngenta Participations AG
Patent: EP1997808 A1, 2008 ;
Location in patent: Page/Page column 5 ;
反应条件
1: N,N-dimethylamino-1,1,2,2-tetrafluoroethane With boron trifluoride diethyl etherate in 1,4-dioxane; diethyl ether T=0 - 5°C; Inert atmosphere; 2: 3-methoxyacrylic acid methyl ester With pyridine in 1,4-dioxane; diethyl ether T=0 - 5°C; 3: methylhydrazine Product distribution / selectivity;
参考文献
BASF SE
Patent: US2010/184994 A1, 2010 ;
Location in patent: Page/Page column 9 ;