4-溴吡啶-2,6-二甲醇合成路线 （共 11 条）
反应条件
sodium tetrahydroborate in ethanol 3 h; Reflux;
参考文献
Bonnet, Celia S.; Buron, Frederic; Caille, Fabien; Shade, Chad M.; Drahos, Bohuslav; Pellegatti, Laurent; Zhang, Jian; Villette, Sandrine; Helm, Lothar; Pichon, Chantal; Suzenet, Franck; Petoud, Stephane; Toth, Eva
Chemistry - A European Journal, 2012 , vol. 18, # 5 p. 1419 - 1431
反应条件
sodium tetrahydroborate in ethanol room temperature, 2 h -> reflux, 15 h;
参考文献
Takalo, Harri; Pasanen, Paavo; Kankare, Jouko
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1988 , vol. 42, # 6 p. 373 - 377
反应条件
sodium tetrahydroborate in ethanol
参考文献
Isis Pharmaceuticals, Inc.
Patent: US6191273 B1, 2001 ;
反应条件
1: PBr3; Br2 / 120 °C 2: NaBH4 / methanol View Scheme
参考文献
Schmidt, Boris; Ehlert, Dennis K.
Tetrahedron Letters, 1998 , vol. 39, # 23 p. 3999 - 4002
反应条件
sodium tetrahydroborate
参考文献
Schmidt, Boris; Ehlert, Dennis K.
Tetrahedron Letters, 1998 , vol. 39, # 23 p. 3999 - 4002
反应条件
1: Br2; PBr3 / ethanol 2: NaBH4 View Scheme
参考文献
Yang, Yin; Li, Qing-Feng; Cao, Chan; Huang, Feng; Su, Xun-Cheng
Chemistry - A European Journal, 2013 , vol. 19, # 3 p. 1097 - 1103
反应条件
1.1: 96 percent / NH4OH / H2O / 5 h / 100 °C 2.1: PBr5 / 2.5 h / 90 °C 2.2: 83 percent / CHCl3 / cooling 3.1: 85 percent / NaBH4 / ethanol / 18 h / Heating View Scheme
参考文献
Gan, Xin-Min; Paine, Robert T.; Duesler, Eileen N.; Noeth, Heinrich
Dalton Transactions, 2003 , # 1 p. 153 - 159
反应条件
1.1: 83 percent / HCl / 20 h / 100 °C 2.1: 96 percent / NH4OH / H2O / 5 h / 100 °C 3.1: PBr5 / 2.5 h / 90 °C 3.2: 83 percent / CHCl3 / cooling 4.1: 85 percent / NaBH4 / ethanol / 18 h / Heating View Scheme
参考文献
Gan, Xin-Min; Paine, Robert T.; Duesler, Eileen N.; Noeth, Heinrich
Dalton Transactions, 2003 , # 1 p. 153 - 159
反应条件
1: 12 h / 0 - 20 °C 2: sodium tetrahydroborate / ethanol / 3 h / Reflux View Scheme
参考文献
Bonnet, Celia S.; Buron, Frederic; Caille, Fabien; Shade, Chad M.; Drahos, Bohuslav; Pellegatti, Laurent; Zhang, Jian; Villette, Sandrine; Helm, Lothar; Pichon, Chantal; Suzenet, Franck; Petoud, Stephane; Toth, Eva
Chemistry - A European Journal, 2012 , vol. 18, # 5 p. 1419 - 1431
反应条件
1: 79 percent / dimethyl sulfoxide-oxalyl chloride, triethylamine / CH2Cl2 / 0.08 h / -60 °C View Scheme
参考文献
Takalo, Harri; Kankare, Jouko
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 2 p. 167 - 169
