4-氯-3-磺酰胺基苯甲酸合成路线 （共 7 条）
反应条件
(i) ClSO3H, NaCl, (ii) liq. NH3; Multistep reaction;
参考文献
J. Med. Chem., , vol. 6, p. 272 - 275
反应条件
1: thionyl chloride / 3 h / |Reflux 2: ammonium hydroxide / 1,4-dioxane / 0.5 h View Scheme
参考文献
Pirotte, Bernard; De Tullio, Pascal; Florence, Xavier; Goffin, Eric; Somers, Fabian; Boverie, Stephane; Lebrun, Philippe
Journal of Medicinal Chemistry, 2013 , vol. 56, # 8 p. 3247 - 3256
反应条件
thionyl chloride Heating;
参考文献
Gubert; Braso; Sacristan; Ortiz
Farmaco, 1990 , vol. 45, # 1 p. 59 - 79
反应条件
1: SOCl2 / Heating 2: diethyl ether View Scheme
参考文献
Hoefle; Blouin; DeWald; Holmes; Williams
Journal of medicinal chemistry, 1968 , vol. 11, # 5 p. 970 - 973
反应条件
dicyclohexyl-carbodiimide in ethanol T=-12 - -4°C; 2 h;
参考文献
Ziobro, Barbara; Sienkiewicz, Barbara; Kowalski, Piotr
Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 1 p. 95 - 97
反应条件
ammonium hydroxide; (NH4)2CO3; copper(II) sulfate
T=130°C; 18 h;
参考文献
Bierbaum,B.A. et al.
J. Med. Chem., 1963 , vol. 6, p. 272 - 275
反应条件
thionyl chloride in N-methyl-acetamide
参考文献
Hoechst Aktiengesellschaft
Patent: US4010273 A1, 1977 ;
